FIGURE
Fig. 5
Fig. 5
Blocking Fgf Signaling Prevents the Initiation of Retina Differentiation (A–H) (A and B) Lateral and (C–H) dorsal views of zebrafish embryos treated for 5 hours (23–28 hpf) with the (B, D, F, and H) Fgf signaling inhibitor SU5402 or (A, C, E, and G) mock solution. (A and B) In contrast to the control embryos, ath5 expression is absent in SU5402-treated embryos. Other genes expressed in the optic stalk (pax2, vax1, and vax2) were not affected by SU5402 treatment (compare [D], [F], and [H] to [C], [E], and [G], respectively). MHB, midbrain-hindbrain boundary; poa, pre-optic area. |
Expression Data
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| Condition: | |
| Anatomical Terms: | |
| Stage: | Prim-5 |
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Cell, 8(4), Martinez-Morales, J.R., Del Bene, F., Nica, G., Hammerschmidt, M., Bovolenta, P., and Wittbrodt, J., Differentiation of the vertebrate retina is coordinated by an FGF signaling center, 565-574, Copyright (2005) with permission from Elsevier. Full text @ Dev. Cell