FIGURE

Fig. 4

ID

ZDB-FIG-080604-16

Publication

Reichenbach et al., 2008 - Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish

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Fig. 4

Hedgehog pathway mutants lack enteric ganglia. (A–I) Dorsal views, anterior to the left. Enteric ganglia colonizing the gut express phox2b in wild type (A, black arrows) while syu^-/- (B) and smu^-/- (C) embryos show no phox2b expression around the gut tube. (D) Expression of ret in 36 hpf wild type embryos in migrating enteric precursors (black arrows). In syu^-/- (E) and smu^-/- (F) no ret expressing migrating cells can be detected. Wild type embryos at 36 hpf show crestin expression in vagal neural crest cells migrating to the anterior gut (G, black arrows). syu^-/- (H) and smu^-/- (I) embryos lack crestin expressing vagal neural crest cells.

Expression Data

Genes:	crestin phox2bb ret
Fish:	WT shha^tq252/tq252 smo^{unspecified/unspecified}
Anatomical Terms:	enteric nervous system presumptive enteric nervous system
Stage Range:	Prim-15 to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 318(1), Reichenbach, B., Delalande, J.M., Kolmogorova, E., Prier, A., Nguyen, T., Smith, C.M., Holzschuh, J., and Shepherd, I.T., Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish, 52-64, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.