FIGURE

Fig. 6

ID

ZDB-FIG-080505-40

Publication

Bertrand et al., 2008 - CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis

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Fig. 6

Hematopoietic precursors migrate along the pronephric tubules. (A) CD41:eGFP (left panel; asterisk marks fluorescence from circulating thrombocytes) and cmyb:eGFP (middle panel) transgenes are expressed in cells along each pronephric tubule. The anterior pronephric tubules are marked by a gata3:AmCyan transgene (right panel). Dorsal views of animals with anterior side upwards. (B) cmyb:eGFP⁺ cells (arrowheads) are localized upon gata-3:AmCyan⁺ pronephric tubules (T). (C) Timelapse imaging demonstrates cmyb:eGFP⁺ cells migrate along the pronephric tubules in an anterior direction. Two GFP⁺ cells (dotted red circle) were observed to migrate ∼190 μm (blue arrow) over 30 hours. Embryos imaged dorsal side upwards, anterior towards the right.

Expression Data

Gene:	EGFP
Fish:	zf169Tg la2Tg; sd2Tg
Anatomical Terms:	hematopoietic stem cell pronephric duct
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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