FIGURE

Fig. 5

ID

ZDB-FIG-080326-24

Publication

Smith et al., 2008 - Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells

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Fig. 5

Leftward Displacement of CPCs and Cardiac Rotation Are Affected upon Reduced or Ectopic BMP Signaling (A–C) Selected images of confocal time-lapse recordings of laf/alk8 (A) heat-shock induced (at 15-somite stage) tg(hsp70:noggin3) (B) and tg(hsp70:bmp2b) (C) embryos with individual cells marked and tracked over a 200 min period. (D) Quantification of clockwise cardiac cone rotation in wild-type laf/alk8 mutant tg(hsp70:noggin3) and tg(hsp70:bmp2b) embryos (mean ± SEM). (E) ISH with a cmlc2 riboprobe on tg(hsp70:bmp2b) embryos heat shocked at various time points (indicated at the top). Arrows and arrowheads indicate CPCs not properly incorporated into the cardiac tube. Heat shock at 15-somite stage, no cardiac jogging (n = 14/16); 18-somite stage, no cardiac jogging (n = 12/20); 22-somite stage, leftward jogging (n = 17/19).

Expression Data

Gene:	myl7
Fish:	fr13Tg; twu34Tg
Condition:	heat shock
Anatomical Term:	heart tube
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	acvr1l^{tm110b/tm110b} fr13Tg fr14Tg fr13Tg; twu34Tg
Condition:	heat shock
Observed In:	cardiac muscle cell embryonic heart tube development heart looping heart rudiment heart tube
Stage Range:	20-25 somites to Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 14(2), Smith, K.A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M., and Bakkers, J., Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells, 287-297, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell