ZFIN Figure: Hendricks et al., 2008, Fig. 2

ZFIN ID: ZDB-FIG-080325-21

ZFIN ID: ZDB-FIG-080325-21

Hendricks et al., 2008 - Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for commissure formation. Molecular and cellular neurosciences 37(2):271-283 Full text @ Mol. Cell Neurosci.

ADDITIONAL FIGURES

PHENOTYPE:

Fish:	mycbp2^tp203/tp203
Observed In:	habenular commissure
Stage:	Protruding-mouth

Fig. 2 The habenular commissure is absent in esrom mutants. (A) Axon tracts in the dorsal forebrain of 3 dpf wt embryo, visualized with an antibody to acetylated tubulin. The habenular commissure (arrow) is visible between the left and right habenulae. (B) An esrom mutant at 3 dpf. The habenular commissure is absent. The posterior commissure is indicated (arrowhead). (C–F) Unilateral electroporation with eGFP, showing the presence of the habenular commissure (arrow, C) and contralateral terminations (arrowheads, E) in a wild type embryo. These are absent in an esrom mutant (D, F). Habenular afferents can be visualized with an antibody to mGluR2/3 (G, H) or SV2 (I, J). The commissure is visible in wild types (arrow, G, I). In mutants (H, J), axons terminate in the ipsilateral neuropils (red arrowheads). All embryos are shown in dorsal view, except panels E and F which are lateral views. rHb: right habenula; lHb left habenula; TeO: tectum opticum. Scale bar = 20 μm.

Gene Expression Details No data available

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
mycbp2^tp203/tp203	standard conditions	Protruding-mouth	habenular commissure aplastic, abnormal

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Reprinted from Molecular and cellular neurosciences, 37(2), Hendricks, M., Mathuru, A.S., Wang, H., Silander, O., Kee, M.Z., and Jesuthasan, S., Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for commissure formation, 271-283, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.

Acknowledgments:

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Molecular and cellular neurosciences, 37(2), Hendricks, M., Mathuru, A.S., Wang, H., Silander, O., Kee, M.Z., and Jesuthasan, S., Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for commissure formation, 271-283, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.