FIGURE

Fig. 5

ID

ZDB-FIG-080325-104

Publication

Yang et al., 2007 - Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Examples of toxicant-responsive genes that are expressed in a highly tissue-restricted manner. (a) 48 hpf vehicle 3 control. Figure 1 indicated the exposure embryo from 96 to 120 hpf and (b) 500 ng/l TCDD-treated embryos hybridized to a cytochrome P450 1A1 antisense probe. TCDD-treated embryos showed increased levels of cytochrome P4501A1 mRNA in blood vessels Arrow, primary head sinus, arrowhead, intersegmental vessel. (c) 72 hpf vehicle control 1 and (d) 60 μg/l MeHg-exposed embryos hybridized to a glutathione peroxidase 1 probe. Embryos showed a reduction of mRNA levels in the gut (arrow). Embryos were treated from 4 to 72 hpf and were then fixed for in situ processing. (e) Control embryo and (f) 500 μg/l CdCl₂-treated embryo hybridized to oncomodulin A antisense mRNA. Oncomodulin A mRNA levels are downregulated in the hair cells of the lateral-line organ (arrow) in response to Cd exposure. (g) Control and (h) Cd-treated embryos hybridized to a thioredoxin antisense probe. Thioredoxin is upregulated in the hair cells of the neuromasts (arrow). Embryos are oriented anterior to the left and dorsal up (a,b,e-h) or with dorsal side facing (c,d). Scale bar represents 220 μm.

Expression Data

Genes:	cyp1a gpx1a pvalb8 txnb
Fish:	WT
Conditions:	chemical treatment: cadmium dichloride chemical treatment: methylmercury chloride chemical treatment: 2,3,7,8-tetrachlorodibenzodioxine
Anatomical Terms:	blood vasculature gut intersegmental vessel lateral line system neuromast primary head sinus whole organism
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genome Biol.