FIGURE

Fig. 7

ID

ZDB-FIG-080323-7

Publication

Londin et al., 2007 - Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling

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Fig. 7

chch-compromised cells migrate to the germ ring and become mesoderm in response to Nodal signals. Transplanted MZoep-LacZ cells to the animal hemisphere of a wild-type host remain within the animal hemisphere at shield stage (A) and are observed in anterior neural structures after 24 hpf (A'). Similar behavior was observed for transplanted MZoep-chch-EnR cells in wild-type hosts (B-B'). Similarly, when donor cells express 12.5 pg xFast1-EnR, along with chch-EnR, migration to the margin is blocked and donor cells are observed in anterior neural structures after 24 hpf (D-D'). Together, these results demonstrate that the migration of the chch inhibited cells to the germ ring and acquisition of mesodermal character depends upon Nodal signaling.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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