FIGURE

Fig. 5

ID

ZDB-FIG-070925-82

Publication

Clements et al., 2005 - LZIC regulates neuronal survival during zebrafish development

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Fig. 5

LZIC morpholinos cause neural tissue degeneration. Embryos injected with 5 ng of LZIC mismatch control MO (LZICmis MO; A–C), LZIC MO1 (D–I), or LZIC MO2 (J–L) at 15 somites. Cell death is apparent in the morphants as opaque tissue (arrows, D, E, G, H, J, K) or at earlier stages of cell death fluorescently stained by acridine orange (C, F, I, L). Telencephalon (red arrows), diencephalon (yellow arrows), midbrain (orange arrowheads), eye (purple arrows), hindbrain (black arrows), and dorsal neural tube (blue arrows). (A, D, G, J) Lateral views, anterior to left. (B, C, E, F, H, I, K, L) Head views, ventral to top.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK/AB + MO1-lzic WIK/AB + MO2-lzic
Knockdown Reagents:	MO1-lzic MO2-lzic
Observed In:	cell death diencephalon eye head hindbrain neural tube dorsal region optic tectum telencephalon whole organism
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 283(2), Clements, W.K., and Kimelman, D., LZIC regulates neuronal survival during zebrafish development, 322-334, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.