FIGURE

Fig. S1

ID

ZDB-FIG-070801-29

Publication

Dworkin et al., 2007 - CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish

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Fig. S1

Immunohistochemical staining of coronal brain sections of adult zebrafish brains shows pCREB+ cells are localized within discrete regions in the olfactory bulb (OB; A-i and B-i), retina (A-ii and B-ii), anterior forebrain (telencephalon; A-iii and B-iii), midbrain (mesencephalon/diencephalon A-iv and B-iv) and hindbrain (cerebellum/ rhombencephalon; A-v and B-v; Magnification A1–5: × 10 and B1–5: × 40). Within the OB (A-i and B-i), pCREB+ cells are observed throughout the layers, as seen in sagittal sections, with a strong concentration at the junction of the ECL and ICL (Bi; white arrow). Within the neurally-derived layers of the retina (A-ii and B-ii), strong immunoreactivity for pCREB is observed in the ganglion cell layer (G), and most cells of the inner nuclear layer (I). As in higher vertebrates, no pCREB+ cells are visible in either the outer nuclear layer (O) or the nuclei of the rod and cone photoreceptors (P).

Expression Data

Gene:	creb1a
Fish:	WT
Anatomical Terms:	caudal tuberal nucleus central caudal thalamic nucleus cerebellum corpus cerebelli dorsal entopeduncular nucleus of ventral telencephalon dorsal telencephalon griseum centrale hindbrain medial longitudinal fasciculus nucleus lateralis valvulae olfactory bulb optic tectum periventricular grey zone pretectal periventricular nucleus retinal ganglion cell layer retinal inner nuclear layer superior raphe nucleus telencephalic ventricle torus longitudinalis torus semicircularis valvula cerebelli ventral entopeduncular nucleus of ventral telencephalon
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 307(1), Dworkin, S., Heath, J.K., Dejong-Curtain, T.A., Hogan, B.M., Lieschke, G.J., Malaterre, J., Ramsay, R.G., and Mantamadiotis, T., CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish, 127-141, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.