FIGURE

Fig. 1

ID

ZDB-FIG-070221-6

Publication

Shepard et al., 2005 - A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

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Fig. 1

A forward genetic screen in zebrafish identified a proliferation mutant, crash&burn.(A) Depiction of the cell-proliferation phenotype (by pH3 staining) of one of the eight mutants isolated in the screen, crash&burn (crb). Embryos are 36-hpf diploids. (B) pH3 staining of crb mutant diploid embryos at 16 hpf. (C) crb has increased numbers of apoptotic cells at 24 hpf as shown by TUNEL staining. (D) Time course of crb and wild type progression from S phase into G₂/Mas shown by BrdUrd incorporation followed by pH3 analysis at varying time points after incorporation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mybl2b^cz226/cz226 (WIK)
Observed In:	cell population proliferation G2/M transition of mitotic cell cycle whole organism
Stage Range:	14-19 somites to Prim-25

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA