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Fig. 1
A forward genetic screen in zebrafish identified a proliferation mutant, crash&burn.(A) Depiction of the cell-proliferation phenotype (by pH3 staining) of one of the eight mutants isolated in the screen, crash&burn (crb). Embryos are 36-hpf diploids. (B) pH3 staining of crb mutant diploid embryos at 16 hpf. (C) crb has increased numbers of apoptotic cells at 24 hpf as shown by TUNEL staining. (D) Time course of crb and wild type progression from S phase into G2/Mas shown by BrdUrd incorporation followed by pH3 analysis at varying time points after incorporation.
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