FIGURE

Fig. 2

ID

ZDB-FIG-060717-20

Publication

Hollway et al., 2006 - Scube2 mediates Hedgehog signalling in the zebrafish embryo

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Fig. 2

Slow muscle formation is disrupted in homozygous youmutants. (A–H) Slow myosin heavy chain protein (SMHC) is reduced compared to wild type panels A, C, E, G in you^ty97 homozygote mutant embryos panels B, D, F, H at 10-somite (A, B) and 26-somite stages (C–H). Panels E, F anterior somites, (G, H) posterior, tail extension somites. (E–H) 3D confocal projections of left sided myotomes. (I, J) At 26 somites, Prox1 protein, a specific marker of slow muscle cells, is reduced or absent compared to wild type (I) within the myotome of you^ty97 homozygous embryos (J). A–B dorsal confocal sections, at the level of the notochord, anterior to the left. (C–J) Lateral views anterior to the left.

Expression Data

Genes:	prox1a smyhc1
Fish:	WT scube2^ty97/ty97
Anatomical Terms:	myotome slow muscle cell unspecified
Stage Range:	10-13 somites to 26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 294(1), Hollway, G.E., Maule, J., Gautier, P., Evans, T.M., Keenan, D.G., Lohs, C., Fischer, D., Wicking, C., and Currie, P.D., Scube2 mediates Hedgehog signalling in the zebrafish embryo, 104-118, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.