FIGURE

Fig. 3

ID

ZDB-FIG-060522-4

Publication

Stewart et al., 2006 - Zebrafish foxd3 is selectively required for neural crest specification, migration and survival

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Fig. 3

Abnormal pharyngeal arch development in sym1 mutants. Wild-type (A, B) and sym1 mutant (C, D) embryos at 5 dpf, stained with Alcian blue to reveal craniofacial cartilages. Ventral (A, C) and lateral (B, D) views show that the 1st (mk) and 2nd (ch) arch derivatives are present but abnormal in sym1 mutants, whereas 3rd arch-derived cartilages (cb1–5) are missing altogether. dlx2 expression in migrating neural crest pharyngeal arch precursors, shown in dorsal views at 24 hpf in wild-type (E) and sym1 mutant (G) embryos, and in lateral views of 32 hpf wild-type (F) and sym1 mutant (H) embryos. sym1 mutants have reduced dlx2 expression in migrating neural crest cells that generate the 1st and 2nd arch derivatives (labeled 1 and 2), and more severely reduced dlx2 expression in neural crest cells that generate the pharyngeal cartilages (labeled 3 and 4; G, H). Abbreviations: Meckel's cartilage (mk), palatoquadrate (pq), ceratohyal arch (ch), ethmoid plate (ep), and ceratobranchial (cb) arches 1–5.

Expression Data

Gene:	dlx2a
Fish:	WT foxd3^zdf10/zdf10
Anatomical Term:	pharyngeal arch
Stage Range:	Prim-5 to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 292(1), Stewart, R.A., Arduini, B.L., Berghmans, S., George, R.E., Kanki, J.P., Henion, P.D., and Look, A.T., Zebrafish foxd3 is selectively required for neural crest specification, migration and survival, 174-188, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.