FIGURE

Fig. 6

ID

ZDB-FIG-060426-3

Publication

Reugels et al., 2006 - Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio

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Fig. 6

A-H: Comparison of Numb(PTB^L PRR^L):EGFP, Numb(PTB^S PRR^L):EGFP, Nbl:EGFP, and five different Numb:EGFP deletion constructs with respect to their localization in dividing cells. Confocal micrographs showing a dorsal view of mitotic cells in the neural tube of embryos injected with the corresponding mRNA. Anterior is towards the top and the midline/apical surface is approximately in the middle of each photograph. See text for details. B-D: Note that the nucleus in non-dividing cells is free of the signal (arrow), whereas in mitotic cells (arrowhead) the signal is found in the entire cell, after the nuclear membrane has broken down. F: Amino acids 1-196 (including the PTB^L insertion) are efficiently localized to the basolateral cortex. G: Deletion of amino acids 2-12 impairs cortical and abolishes basolateral localization in dividing cells. H: Impairment of cortical localization is enhanced after deletion of amino acids 2-22.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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