FIGURE

Fig. 2

ID

ZDB-FIG-060203-17

Publication

Cunliffe et al., 2006 - Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS

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Fig. 2

Expression of olig2 in the ventral hindbrain is mediated by hedgehog signalling and strictly dependent on hdac1 function. (A–J) Expression of olig2 in hindbrain of (A,C,E,G,I) wild-type sibling, (B) smoothened (smoh) mutant and (D,F,H,J) hdac1 mutant embryos at (A,B) 32 hpf, (C,D,E,F) 28 hpf and (G,H,I,J) 50 hpf. Panels A–D and G,H show transverse sections through the hindbrain of embryos at the level of rhombomere 5, panels E,F,I,J show dorsal views of (E,I) wild-type and (F,J) hdac1 mutant hindbrain, demonstrating that early expression of olig2 in r5/r6 and later expression throughout the ventral medial hindbrain is strictly hdac1-dependent.

Expression Data

Gene:	olig2
Fish:	WT hdac1^hi1618Tg smo^hi1640Tg
Anatomical Terms:	hindbrain rhombomere 5 rhombomere 6
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 123(1), Cunliffe, V.T., and Casaccia-Bonnefil, P., Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS, 24-30, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.