Genomic Feature
ihb153
- ID
- ZDB-ALT-170608-5
- Name
- ihb153
- Synonyms
-
- M1 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Zhan Yin Lab
- Current Source
- China Zebrafish Resource Center (CZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 27691750 - 27691757 (GRCz11) (1) Details
- Nucleotide change
- TTCGCCAG/-
- Variant Notes
-
Mutation results in a truncated 72 amino acid protein.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CACAGTCATTGAATGAATCAGAGGTTTTTTGAATGAACGTTGACAAACCACTAGTTCAAAGAAATGATTCCATTGCGAAGTCCCTCGTTGGATATTTTTGGGCAGGCGTGGTCACATATGTCGCAATATACAAAGAAGAGCCCGCTTGGAAACGCAGCAGTGACCGCCTGCCCTAATGAGAGGAAACGAGTCTGAATTCTCGCGATCAATAGTTCTGACCAGCGTTTAATCAAAAACGCAATGCAAGTTAATCCAAAGCGCTCATCCCGCCAGCCAATCTTAGGCTTTAAGAGGCGGGGGATAAAGAGCAACATGTGCAAGATGATCCCCTAATACACTGTCCGACAGAGAACGGAGCGCTAGAAACTTTTCAGATTACCCCAAGTTTGCATCTAAGATGATATCGATCAAACGCTTAACATCACCGCTCTCCTTGTCCTGGGAGCAGACGCTGATATGTTTGCTCGGTTTGTTCACGACACTCTTGATTCTGCTGGTGA
TTCGCCAG/- CTCGTAAAGCAGCGGAGACCCCGAGGGTTTCCCCCCGGACCGACACCTTTGCCCATTATAGGGAATATGCTTTCCCTCGCCACAGAGCCTCACGTCTACATGAAGAGGCAGAGTGACATCCACGGACAGGTACAGTAATATAATAATTAGATATTCAGAAATACAGTTGACTTGTTGAGTTTCTTGCTTTTAACGTTATACATTTTTTTGTGCGCGCGGCCGTCAGTTAGGCTTTGCTTCTTTAAAAAGTTATTTTTAGTAATCACGTGATGATAATTATTATTTTGCATAGCAGTGTAATGCATCTTGTAATATAGCCTAATCAATGAAGAGGTATACTTTGCGGCGCGTCGCGTTTAGATTAAGTCTGACGCGCTGCACAGCTGTTCTGCATCACTGTCCCCCTAGGGGGAATTATATATAGCTATGGAAAAAATAGATTTTATTTAAAAATATAATAATAATTTATTAGTTATTTTCATGCAAAGTTACTCCAGCAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cyp2r1ihb153/ihb153 | Homozygous | ♀+/- ♂+/- | 10 figures  from Peng et al., 2017 | 5 figures from Peng et al., 2017 | |
| cyp2r1ihb153/ihb153 | Homozygous | Unknown | Fig. 2 from Shao et al., 2022 | Fig. 4 from Shao et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Liang, S., Zhang, H., Jiao, L., Shao, R., Lan, Y., Liao, X., Mai, K., Ai, Q., Wan, M. (2024) Vitamin D promotes the folate transport and metabolism in zebrafish (Danio rerio). American journal of physiology. Endocrinology and metabolism. 326(4):E482-E492
- Shao, R., Liao, X., Lan, Y., Zhang, H., Jiao, L., Du, Q., Han, D., Ai, Q., Mai, K., Wan, M. (2022) Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22330
- Liao, X., Lan, Y., Shao, R., Liu, J., Liang, S., Yin, Z., Gudmundsson, G.H., Bergman, P., Wan, M. (2021) Vitamin D Enhances Neutrophil Generation and Function in Zebrafish (Danio rerio). Journal of Innate Immunity. 14(3):229-242
- Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z. (2017) Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3.. Cell Reports. 19:1444-1455
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