Genomic Feature
umo5
- ID
- ZDB-ALT-170404-11
- Name
- umo5
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Wei Ge Lab
- Current Source
- China Zebrafish Resource Center (CZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 18: 39631859 - 39631863 (GRCz11) (1) Details
- Nucleotide change
- ATCCC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GATAGCTTTAGATTTATTAATGACAATAATGCATTTCATAATATATAATACATTCTTACTTAATTCAGTTTGCACTTAAAGGGATAGTTCACCCAAAAACTATTCAACACAAAATGTTAGAATGTTAGAAACCTGTAATCATTGACCTCTATAGAAGGAAAAATAAATCAAAGTCAACTGTTTCCAACATTCTTCAAAATATCTTCTTTTGTGTTGAACAGATAAAGAAACGGGTTTGTGACTAATGAAGACTAATGATGGTAGATGAACTGTCCCTTTATTAAGTATGTTGTTTCAATGTAATTTGTGCTGTTTTTCAAAGTATCTGAAAGTGTCTTTATTTTTCATAAGAGTGTTGTGTGTGTGTGTGTGCGTGCGTGCGTGGATGCGTATTTGTGTGTTTCTGGACTCACCTGCTCAAGATGAGAGTTTCCTCACCATTGATCCAGACACGCACAATGTCTCCATACTTGCTGTTGTAGTAGTTGCTGGCAGTCCCG
ATCCC/- AGACCAGATGAACCGACAGTAGGAGACAACAGGACCCAGACCAAAAAAGAAAGAAGGACCTAAATGAAACACATTTTAGCAAGTCAGTGACATGACATCATTGATCAAAGTCTATTTTAAAGCAGAACTATGTAAGTTGTTTACCTTAAAATAAAGTTCCTATAAAATTATATCAAGTGGTAAAACGACTTTTAAGTTTGAATTCTGACGCTGGGGCTTCCAGAAAGTTGCAATGTGTTGCCTTAAAGGAACACTCTACTTTTTACAATCCCCCATTAGCATCATTACCATTAGCATCTTGCTCAAAAATATTCAAAAGCTTGACTAAATACAACATGTAATAAGACCGACAGAAAATTTAAAGTAGCTTTTTTCTGGGTCAGAAATATGATATGGCTCAGAAAATATTCTCATTCTGGTGTAATAATTCAGGAAATTTGATTTCGCACCATGGCTGCTGCAGGCACAATGTTATTACACAATGCCTATAAAAAGTCTCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cyp19a1aumo5/umo5 | Homozygous | ♀+/- ♂+/- | 6 figures from Song et al., 2019 | Fig. 1 from Zhang et al., 2020 | |
| cyp19a1aumo5/umo5 (AB) | Homozygous | ♀+/- ♂+/- | 2 figures  from Lau et al., 2016 | Fig. 3 from Wu et al., 2020 | |
| cyp19a1aumo5/+ | Heterozygous | ♀+/- ♂+/- | 4 figures from Song et al., 2019 | Fig. 1 from Zhang et al., 2020 | |
| cyp19a1aumo5/+ (AB) | Heterozygous | ♀+/- ♂+/- | 2 figures from 2 publications | ||
| cyp19a1aumo5/+; zf45Tg/+ (AB) | Complex | Fig. 4 from Lau et al., 2016 | |||
| cyp19a1aumo5/umo5; zf45Tg/+ (AB) | Complex | 5 figures from Lau et al., 2016 | Fig. 4 from Lau et al., 2016 | ||
| cyp19a1aumo5/+; dmrt1umo15/+ (AB) | Complex | Fig. 1 from Wu et al., 2020 | |||
| cyp19a1aumo5/+; dmrt1umo15/+; zf45Tg | Complex | Fig. 1 from Wu et al., 2020 | |||
| cyp19a1aumo5/+; dmrt1umo15/umo15 (AB) | Complex | Fig. 1 from Wu et al., 2020 | |||
| cyp19a1aumo5/umo5; dmrt1umo15/+ (AB) | Complex | Fig. 1 from Wu et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Wu, K., Zhai, Y., Qin, M., Zhao, C., Ai, N., He, J., Ge, W. (2023) Genetic evidence for differential functions of figla and nobox in zebrafish ovarian differentiation and folliculogenesis. Communications biology. 6:11851185
- Chen, W., Zhai, Y., Zhu, B., Wu, K., Fan, Y., Zhou, X., Liu, L., Ge, W. (2022) Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism. PLoS Genetics. 18:e1010318e1010318
- Wu, K., Song, W., Zhang, Z., Ge, W. (2020) Disruption of dmrt1 rescues the all-male phenotype of cyp19a1a mutant in zebrafish - A Novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis. Development (Cambridge, England). 147(4):
- Zhang, Z., Zhu, B., Chen, W., Ge, W. (2020) Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish. Molecular and Cellular Endocrinology. 517:110963
- Song, W., Lu, H., Wu, K., Zhang, Z., Shuk-Wa Lau, E., Ge, W. (2019) Genetic evidence for estrogenicity of bisphenol A in zebrafish gonadal differentiation and its signalling mechanism. Journal of hazardous materials. 386:121886
- Lau, E.S., Zhang, Z., Qin, M., Ge, W. (2016) Knockout of Zebrafish Ovarian Aromatase Gene (cyp19a1a) by TALEN and CRISPR/Cas9 Leads to All-male Offspring Due to Failed Ovarian Differentiation. Scientific Reports. 6:37357
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