Genomic Feature
y82
- ID
- ZDB-ALT-060125-6
- Name
- y82
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Dawid Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 14: 23613539 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A in Donor Splice Site (1)
- Transcript Consequence
- Cryptic Donor Splice Site, Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ACAAAATACGATGCCACCTTCAAGTGCACCCATAATTTGAAATAAAATAGTCACATGGAAAAAAGACGAAAACTTTTAACCAAACTGGATCTTTGTCCTTGTGTGTTTGTGAAGCTGAGCCTGGGAACGAGAGTGAGCGAGTGGAGTTCTCTAACCTTGTGCTCCTGTTCTACGAGCTCATCCGTCATGATGTCTTCTCACACAACATCTACATGTGCACCCTTATATCCCGTGGGGACCTGGCCTCCAACTCTCATCTGCCCCGCCCTCGTTCCCCCAGCGATGAGCCCTCTGATGAGTCAGAGCGCAAGGACCAGGATGCAGGAAGTAGTGTTAAAATCGAGGCAAGTGACTTTTTTTTTTTTTTTGACTACATTGTAATGGAATGTGATTAGTTGGATTGAGTCGTACATTACTCTCAGCATTTATGTTATTTTCAGGATACTGGTATGTCCGAGTCGATGGAGATAGATCACAACTCAAGCGCTAACTTTGATGAG
G/A TTGGTAAGAGTATTTTGTGTTAGTGATGTTTAACATAAGGCAGTATATAATCGGATCATCATCTGAACCTTCAGCAGATGTTTTCTCCTCCAATGCACTGTGAGTCGAAGGGAAGCCCTTCTCCAGAGAAACAAGCCCAAGAGCAGGAGAGCAAAAGCACTGCCAAGGATAAGGGCATGGACCCAGCCTTCCCTTTGGTTTATGAACAGCCCCGCCACATACAGTACGCCACCCACTTCCCCATTCCTCAGGTGAGCTCTCCTAGGATTGTTTTCACAAAATAATATAAAACTACAAAATAAGTTTTATTTATTTGAGTAGAAAAGTTTGTCACTTGCTATTTTGTTTATCATTCATAAATTGATAACATACAAATTTGAAATACATCTTAAAATGACAATAAAATGGTGAAGTTTTCAAAAAAATGTATTATGGACTGGCCATAATGTGCAGTCTTAATACACTGCTGTTATTTTTGAAAAGTAATGTACTTTTATTCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| med12y82/y82 | Homozygous | Unknown | Fig. for (y82) from Phenotype Annotation (1994-2006) | 5 figures  from Hong et al., 2005 | |
| med12y82/y82 | Homozygous | ♀+/- ♂+/- | 7 figures from 3 publications | 6 figures from 2 publications | |
| med12y82/+ (AB) | Heterozygous | Unknown | |||
| med12y82/y82; e1Tg | Complex | Fig. 3 from Hong et al., 2011 | Fig. 3 from Hong et al., 2011 | ||
| med12y82/y82; ml1Tg | Complex | Fig. 4 from Coffey et al., 2013 | |||
| med12y82/y82; rw0Tg | Complex | Fig. 4 from Coffey et al., 2013 | |||
| med12y82/y82; w25Tg/+ | Complex | Fig. 3 from Spikol et al., 2018 | |||
| apchu745/hu745; med12y82/y82 | Complex | Fig. 3 from Spikol et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Spikol, E.D., Glasgow, E. (2018) Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression. Biology Open. 7(3)
- Wu, S.Y., de Borsetti, N.H., Bain, E.J., Bulow, C.R., and Gamse, J.T. (2014) Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Developmental Biology. 385(1):13-22
- Coffey, C.M., Solleveld, P.A., Fang, J., Roberts, A.K., Hong, S.K., Dawid, I.B., Laverriere, C.E., and Glasgow, E. (2013) Novel oxytocin gene expression in the hindbrain is induced by alcohol exposure: transgenic zebrafish enable visualization of sensitive neurons. PLoS One. 8(1):e53991
- Hong, S.K., and Dawid, I.B. (2011) The transcriptional mediator component med12 is required for hindbrain boundary formation. PLoS One. 6(4):e19076
- Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18473-18478
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