Gene

med12

ID
ZDB-GENE-060125-1
Name
mediator complex subunit 12
Symbol
med12 Nomenclature History
Previous Names
  • kgt (1)
  • king tut (1)
  • kohtalo
  • kto
  • mot_m807
  • motionless
  • ott (1)
  • otter (1)
  • shiri (1)
  • shr (1)
  • thyroid hormone receptor-associated protein 230 (1)
  • trap230 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity. Involved in several processes, including animal organ development; embryonic pectoral fin morphogenesis; and iridophore differentiation. Predicted to localize to mediator complex. Is expressed in several structures, including brain; head; immature eye; intermediate cell mass of mesoderm; and liver. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disability. Orthologous to several human genes including MED12 (mediator complex subunit 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
37 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With med12 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
FG syndrome Alliance Opitz-Kaveggia syndrome 305450
Ohdo syndrome Alliance Ohdo syndrome, X-linked 300895
Lujan-Fryns syndrome 309520
Associated With med12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR019035 Mediator complex, subunit Med12
Domain IPR021989 Mediator complex, subunit Med12, catenin-binding
Domain IPR021990 Mediator complex, subunit Med12, LCEWAV-domain
Domain Details Per Protein
Protein Length Mediator complex, subunit Med12 Mediator complex, subunit Med12, catenin-binding Mediator complex, subunit Med12, LCEWAV-domain
UniProtKB:Q2QCI8 2173
UniProtKB:A0A0R4IEY1 267
UniProtKB:A0A0R4IBL3 2175
UniProtKB:G3KFY4 2169
UniProtKB:A0A2R8QEP6 2188
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations