ZFIN ID: ZDB-LAB-970908-15
Dawid Lab
PI/Director: Dawid, Igor B.
Contact Person: Dawid, Igor B.
Email: idawid@mail.nih.gov
URL: http://sdb.nichd.nih.gov/index.html
Address: Laboratory of Molecular Genetics Program in Genomics of Differentiation Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Building 6B, Room 422 Bethesda, MD 20892 USA
Country: United States
Phone: (301) 496-9689
Fax: (301) 496-0243
Line Designation: y

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The molecular basis of vertebrate embryogenesis in the zebrafish Danio rerio and the amphibian Xenopus laevis is the focus of the research in this group. As a broad approach to this question a screen for genes expressed in differential patterns during embryogenesis has been carried out in the zebrafish. Over 300 of these clones were considered suitable for further study by partial sequence analysis and radiation hybrid mapping. Information on these genes is available on ZFIN and the laboratory web site. To help develop tools for molecular-genetic analysis of zebrafish development this laboratory collaborated with others on the establishment and refinement of a radiation hybrid map for this organism. A mapping tool is available on the laboratory web site.

Mutants affecting the development of the brain are being studied, showing in one example that ribosome biogenesis is essential for this process during the first 24 hr of embryogenesis. The role of several genes in early development has been studied. These include nodal-related factors, the vega1, 2 (vent, vox) homeobox genes, and gadd45 that is involved in somitogenesis. The Nma protein has been shown to be a feedback inhibitor of BMP signaling, while Wif1 is a Wnt binding protein that can inhibit the activity of several Wnt proteins. Much attention has been focused on factors modulating FGF signaling; Sef, a novel protein, and Mkp3, a MAP kinase phosphatase, were shown to modulate Fgf signaling in the early embryo. A long-standing interest in this laboratory concerns the role of the LIM-homeobox gene Lim1 which is being studied in Xenopus. Lim1 function requires interaction with a binding molecule, named Ldb, whose properties have also been studied. Lim1 is expressed in the organizer where it has a major role in controlling gastrulation movements through its activation of the adhesion molecule PAPC.

The application of DNA microarray technology is being explored in both the Xenopus and zebrafish systems. RNA expression profiles in explants dissected from the embryo and after manipulation of different signaling pathways are being generated.

Organisms: Xenopus laevis (African clawed frog), Danio rerio (zebrafish).

Genes of Interest: Xlim-1 (lim1, Lhx-1), Ldb, nodal related factors (cyclops), vega1 (vox), vega2 (vent), Wif1, nma, iroquis group genes, sef, mkp3, bap28.

Kim, Miha Post-Doc Ro, Hyunju Post-Doc Won, Minho Post-Doc
Zarelli, Valeria Post-Doc Rebbert, Martha Research Staff Gonzales, John Fish Facility Staff

Heffer, A., Marquart, G.D., Aquilina-Beck, A., Saleem, N., Burgess, H.A., Dawid, I.B. (2017) Generation and characterization of Kctd15 mutations in zebrafish. PLoS One. 12:e0189162
Kim, K.I., Jeong, H.B., Ro, H., Lee, J.H., Kim, C.D., Yoon, T.J. (2017) Inhibitory effect of 5-iodotubercidin on pigmentation. Biochemical and Biophysical Research Communications. 490(4):1282-1286
Yoo, K.W., Maddirevula, S., Kumar, A., Ro, H., Huh, T.L., Rhee, M. (2017) Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos. Animal cells and systems. 21:93-99
Won, M., Dawid, I.B. (2017) PCR artifact in testing for homologous recombination in genomic editing in zebrafish. PLoS One. 12:e0172802
Kim, M.K., Bang, C.Y., Kim, M.Y., Lee, J.H., Ro, H., Choi, M.S., Kim, D.I., Jang, Y.P., Choung, S.Y. (2016) Traditional herbal prescription LASAP-C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish. BMC complementary and alternative medicine. 16:223
Won, M., Lee, S., Choi, S., Ro, H., Kim, K.J., Kim, J.H., Kim, K.E., Kim, K.K. (2016) Identification and characterization of the RNA-binding protein Rbfox3 in zebrafish embryo. Biochemical and Biophysical Research Communications. 472(2):373-8
Won, M., Ro, H., Dawid, I.B. (2015) Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas. Proceedings of the National Academy of Sciences of the United States of America. 112(40):12426-31
Komiya, Y., Mandrekar, N., Sato, A., Dawid, I.B., Habas, R. (2014) Custos controls β-catenin to regulate head development during vertebrate embryogenesis. Proc. Natl. Acad. Sci. USA. 111(36):13099-104
Kang, N., Won, M., Rhee, M., Ro, H. (2014) Siah Ubiquitin Ligases Modulate Nodal Signaling during Zebrafish Embryonic Development. Molecules and cells. 37(5):389-98
Kim, M.H., Rebbert, M.L., Ro, H., Won, M., Dawid, I.B. (2014) Cell adhesion in zebrafish embryos is modulated by march8. PLoS One. 9:e94873
Gonzales, J.M., and Law, S.H. (2013) Feed and Feeding Regime Affect Growth Rate and Gonadosomatic Index of Adult Zebrafish (Danio Rerio). Zebrafish. 10(4):532-40
Zarelli, V.E., and Dawid, I.B. (2013) The BTB-Containing Protein Kctd15 Is SUMOylated In Vivo. PLoS One. 8(9):e75016
Toyama, R., Kim, M.H., Rebbert, M.L., Gonzales, J., Burgess, H., and Dawid, I.B. (2013) Habenular commissure formation in zebrafish is regulated by the pineal gland-specific gene unc119c. Developmental dynamics : an official publication of the American Association of Anatomists. 242(9):1033-42
Zarelli, V.E., and Dawid, I.B. (2013) Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Proc. Natl. Acad. Sci. USA. 110(8):2870-2875
Coffey, C.M., Solleveld, P.A., Fang, J., Roberts, A.K., Hong, S.K., Dawid, I.B., Laverriere, C.E., and Glasgow, E. (2013) Novel oxytocin gene expression in the hindbrain is induced by alcohol exposure: transgenic zebrafish enable visualization of sensitive neurons. PLoS One. 8(1):e53991
Park, H., Song, K.H., Jung, P.M., Kim, J.E., Ro, H., Kim, M.Y., and Ma, J.Y. (2013) Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression. Evidence-Based Complementary and Alternative Medicine. 2013:965312
Gonzales, J.M. (2012) Preliminary Evaluation on the Effects of Feeds on the Growth and Early Reproductive Performance of Zebrafish (Danio rerio). Journal of the American Association for Laboratory Animal Science. 51(4):412-417
Kawahara, A., Endo, S., and Dawid, I.B. (2012) Vap (Vascular Associated Protein): A novel factor involved in erythropoiesis and angiogenesis. Biochemical and Biophysical Research Communications. 421(2):367-374
Takesono, A., Moger, J., Faroq, S., Cartwright, E., Dawid, I.B., Wilson, S.W., and Kudoh, T. (2012) Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Proc. Natl. Acad. Sci. USA. 109(9):3371-3376
Ro, H., and Dawid, I.B. (2011) Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. The EMBO journal. 30(14):2894-907
Hong, S.K., and Dawid, I.B. (2011) The transcriptional mediator component med12 is required for hindbrain boundary formation. PLoS One. 6(4):e19076
Dente, L., Gestri, G., Tsang, M., Kudoh, T., Wilson, S.W., Dawid, I.B., and Andreazzoli, M. (2011) Cloning and developmental expression of zebrafish pdzrn3. The International journal of developmental biology. 55(10-12):989-993
Ro, H., and Dawid, I.B. (2010) Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity. Biochemical and Biophysical Research Communications. 402(4):626-630
Aamar, E., and Dawid, I.B. (2010) Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 239(11):2980-2988
Dutta, S., and Dawid, I.B. (2010) Kctd15 inhibits neural crest formation by attenuating Wnt/β-catenin signaling output. Development (Cambridge, England). 137(18):3013-3018
Znosko, W.A., Yu, S., Thomas, K., Molina, G.A., Li, C., Tsang, W., Dawid, I.B., Moon, A.M., and Tsang, M. (2010) Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Developmental Biology. 342(1):11-25
Cruz, C., Maegawa, S., Weinberg, E.S., Wilson, S.W., Dawid, I.B., and Kudoh, T. (2010) Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos. Proc. Natl. Acad. Sci. USA. 107(8):3564-3569
Swanhart, L.M., Takahashi, N., Jackson, R.L., Gibson, G.A., Watkins, S.C., Dawid, I.B., and Hukriede, N.A. (2010) Characterization of an lhx1a transgenic reporter in zebrafish. The International journal of developmental biology. 54(4):731-736
Ro, H., and Dawid, I.B. (2009) Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nat. Cell Biol.. 11(9):1121-1127
Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D.C., and Dawid, I.B. (2009) Transcriptome analysis of the zebrafish pineal gland. Developmental dynamics : an official publication of the American Association of Anatomists. 238(7):1813-1826
Hong, S.K., and Dawid, I.B. (2009) FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. Proc. Natl. Acad. Sci. USA. 106(7):2230-2235
Brown, J.D., Dutta, S., Bharti, K., Bonner, R.F., Munson, P.J., Dawid, I.B., Akhtar, A.L., Onojafe, I.F., Alur, R.P., Gross, J.M., Hejtmancik, J.F., Jiao, X., Chan, W.Y., and Brooks, B.P. (2009) Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proc. Natl. Acad. Sci. USA. 106(5):1462-1467
Sperber, S.M., and Dawid, I.B. (2008) barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches. Developmental Biology. 321(1):101-110
Aamar, E., and Dawid, I.B. (2008) Protocadherin-18a has a role in cell adhesion, behavior and migration in zebrafish development. Developmental Biology. 318(2):335-346
Toyama, R., Rebbert, M.L., Dey, A., Ozato, K., and Dawid, I.B. (2008) Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 237(6):1636-1644
Hong, S.K., Tsang, M., and Dawid, I.B. (2008) The Mych Gene Is Required for Neural Crest Survival during Zebrafish Development. PLoS One. 3(4):e2029
Zhao, H., Tanegashima, K., Ro, H., and Dawid, I.B. (2008) Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways. Development (Cambridge, England). 135(7):1283-1293
Aamar, E., and Dawid, I.B. (2008) Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos. The International journal of developmental biology. 52(7):985-991
Hong, S.K., and Dawid, I.B. (2008) Alpha2 macroglobulin-like is essential for liver development in zebrafish. PLoS One. 3(11):e3736
Hanaoka, R., Dawid, I.B., and Kawahara, A. (2007) Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO). DNA sequence : the journal of DNA sequencing and mapping. 18(1):54-60
Pugacheva, E.M., Kwon, Y.W., Hukriede, N.A., Pack, S., Flanagan, P.T., Ahn, J.C., Park, J.A., Choi, K.S., Kim, K.W., Loukinov, D., Dawid, I.B., and Lobanenkov, V.V. (2006) Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization. Gene. 375:26-36
Azuma, M., Toyama, R., Laver, E., and Dawid, I.B. (2006) Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system. The Journal of biological chemistry. 281(19):13309-13316
Hanaoka, R., Katayama, S., Dawid, I.B., and Kawahara, A. (2006) Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis. Genes to cells : devoted to molecular & cellular mechanisms. 11(3):293-303
Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc. Natl. Acad. Sci. USA. 102(51):18473-18478
Takahashi, N., and Dawid, I.B. (2005) Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Nucleic acids research. 33(13):e120
Kawahara, A., Che, Y.S., Hanaoka, R., Takeda, H., and Dawid, I.B. (2005) Zebrafish GADD45{beta} genes are involved in somite segmentation. Proc. Natl. Acad. Sci. USA. 102(2):361-366
Kudoh, T., Concha, M.L., Houart, C., Dawid, I.B., and Wilson, S.W. (2004) Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development (Cambridge, England). 131(15):3581-3592
Tsang, M., Maegawa, S., Kiang, A., Habas, R., Weinberg, E., and Dawid, I.B. (2004) A role for MKP3 in axial patterning of the zebrafish embryo. Development (Cambridge, England). 131(12):2769-2779
Appelbaum, L., Toyama, R., Dawid, I.B., Klein, D.C., Baler, R., and Gothilf, Y. (2004) Zebrafish serotonin-N-acetyltransferase-2 gene regulation: Pineal-restrictive downstream module (PRDM) contains a functional E-box and three photoreceptor conserved elements. Molecular endocrinology (Baltimore, Md.). 18(5):1210-1221
Toyama, R., Gomez, D.M., Mana, M.D., and Dawid, I.B. (2004) Sequence relationships and expression patterns of zebrafish zic2 and zic5 genes. Gene Expression Patterns. 4(3):345-350
Ro, H., Soun, K., Kim, E.J., and Rhee, M. (2004) Novel Vector Systems Optimized for Injecting in vitro-synthesized mRNA into Zebrafish Embryos. Molecules and cells. 17(2):373-376
Preger, E., Ziv, I., Shabtay, A., Sher, I., Tsang, M., Dawid, I.B., Altuvia, Y., and Ron, D. (2004) Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Proc. Natl. Acad. Sci. USA. 101(5):1229-1234
Piotrowski, T., Ahn, D.-G., Schilling, T.F., Nair, S., Ruvinsky, I., Geisler, R., Rauch, G.-J., Haffter, P., Zon, L.I., Zhou, Y., Foott, H., Dawid, I.B., and Ho, R.K. (2003) The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development (Cambridge, England). 130(20):5043-5052
Solomon, K.S., Kudoh, T., Dawid, I.B., and Fritz, A. (2003) Zebrafish foxi1 mediates otic placode formation and jaw development. Development (Cambridge, England). 130(5):929-940
Kawahara, A. and Dawid, I.B. (2002) Developmental expression of zebrafish emx1 during early embryogenesis. Gene Expression Patterns. 2(3-4):201-206
Watanabe, M., Rebbert, M.L., Andreazzoli, M., Takahashi, N., Toyama, R., Zimmerman, S., Whitman, M., and Dawid, I.B. (2002) Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Developmental dynamics : an official publication of the American Association of Anatomists. 225(4):448-456
Gothilf, Y., Toyama, R., Coon, S.L., Du, S.-J., Dawid, I.B., and Klein, D.C. (2002) Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 225(3):241-249
Kudoh, T., Wilson, S.W., and Dawid, I.B. (2002) Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. Development (Cambridge, England). 129(18):4335-4346
Kawahara, A., Chien, C.-B., and Dawid, I.B. (2002) The homeobox gene mbx is involved in eye and tectum development. Developmental Biology. 248(1):107-117
Hong, S.K., Kim, C.-H., Yoo, K.-W., Kim, H.S., Kudoh, T., Dawid, I.B., and Huh, T.L. (2002) Isolation and expression of a novel neuron-specific onecut homeobox gene in zebrafish. Mechanisms of Development. 112(1-2):199-202
Miyamoto, T., Kawahara, A., Teufel, A., Mukhopadhyay, M., Zhao, Y., Dawid, I.B., and Westphal, H. (2002) Mbx, a novel mouse homeobox gene. Development genes and evolution. 212(2):104-106
Tsang, M., Friesel, R., Kudoh, T., and Dawid, I.B. (2002) Identification of Sef, a novel modulator of FGF signalling. Nat. Cell Biol.. 4(2):165-169
Hibi, M., Hirano, T., and Dawid, I.B. (2002) Organizer formation and function. Results Probl. Cell Diff.. 40:48-71
Hukriede, N., Fisher, D., Epstein, J., Joly, L., Tellis, P., Zhou, Y., Barbazuk, B., Cox, K., Fenton-Noriega, L., Hersey, C., Miles, J., Sheng, X., Song, A., Waterman, R., Johnson, S.L., Dawid, I.B., Chevrette, M., Zon, L.I., McPherson, J., and Ekker, M. (2001) The LN54 radiation hybrid map of zebrafish expressed sequences. Genome research. 11(12):2127-2132
Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. Genome research. 11(12):1979-1987
Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. ZFIN Direct Data Submission.
Kudoh, T. and Dawid, I.B. (2001) Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards. Mechanisms of Development. 109(1):95-98
Kawahara, A. and Dawid, I.B. (2001) Critical role of biklf in erythroid cell differentiation in zebrafish. Current biology : CB. 11(17):1353-1357
Kudoh, T. and Dawid, I.B. (2001) Role of the iroquois3 homeobox gene in organizer formation. Proc. Natl. Acad. Sci. USA. 98(14):7852-7857
Andreazzoli, M., Broccoli, V., and Dawid, I.B. (2001) Cloning and expression of noz1, a zebrafish zinc finger gene related to Drosophila nocA. Mechanisms of Development. 104(1-2):117-120
Dawid, I.B. and Chitnis, A.B. (2001) Lim homeobox genes and the CNS: a close relationship. Neuron. 30(2):301-303
Kawahara, A., Wilm, T., Solnica-Krezel, L., and Dawid, I.B. (2000) Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation. Proc. Natl. Acad. Sci. USA. 97(22):12121-12126
Kawahara, A. and Dawid, I.B. (2000) Expression of the Kruppel-like zinc finger gene biklf during zebrafish development. Mechanisms of Development. 97(1-2):173-176
Kawahara, A., Wilm, T., Solnica-Krezel, L., and Dawid, I.B. (2000) Functional interaction of vega2 and goosecoid homeobox genes in zebrafish. Genesis (New York, N.Y. : 2000). 28(2):58-67
Tsang, M., Kim, R., De Caestecker, M.P., Kudoh, T., Roberts, A.B., and Dawid, I.B. (2000) Zebrafish nma is involved in TGFb family signaling. Genesis (New York, N.Y. : 2000). 28(2):47-57
Kodjabachian, L., Dawid, I.B., and Toyama, R. (1999) Gastrulation in zebrafish: what mutants teach us. Developmental Biology. 213(2):231-245
Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proc. Natl. Acad. Sci. USA. 96(17):9745-9750
Hsieh, J.C., Kodjabachian, L., Rebbert, M.L., Rattner, A., Smallwood, P.M., Samos, C.H., Nusse, R., Dawid, I.B., and Nathans, J. (1999) A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 398(6726):431-436
Chitnis, A.B. and Dawid, I.B. (1999) Neurogenesis in zebrafish embryos. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:367-386
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Kobayashi, M., Toyama, R., Takeda, H., Dawid, I.B., and Kawakami, K. (1998) Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (Cambridge, England). 125:2973-2982
Rebagliati, M.R., Toyama, R., Fricke, C., Haffter, P., and Dawid, I.B. (1998) Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Developmental Biology. 199:261-272
Dawid, I.B., Breen, J.J., and Toyama, R. (1998) LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends in genetics : TIG. 14(4):156-162
Toyama, R., Kobayashi, M., Tomita, T., and Dawid, I.B. (1998) Expression of LIM-domain binding protein (ldb) genes during zebrafish embryogenesis. Mechanisms of Development. 71:197-200
Glasgow, E., Karavanov, A.A., and Dawid, I.B. (1997) Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects. Developmental Biology. 192:405-419
Toyama, R. and Dawid, I.B. (1997) lim6, a novel LIM homeobox gene in the zebrafish: Comparison of its expression pattern with lim1. Developmental dynamics : an official publication of the American Association of Anatomists. 209(4):406-417
Minucci, S., Leid, M., Toyama, R., Saint-Jeannet, J.P., Peterson, V.J., Horn, V., Ishmael, J.E., Bhattacharyya, N., Dey, A., Dawid, I.B., and Ozato, K. (1997) Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Molecular and cellular biology. 17(2):644-655
Sheng, H.Z., Bertuzzi, S., Chiang, C., Shawlot, W., Taira, M., Dawid, I., and Westphal, H. (1997) Expression of murine Lhx5 suggests a role in specifying the forebrain. Developmental dynamics : an official publication of the American Association of Anatomists. 208(2):266-277
Minucci, S., Saint-Jeannet, J.P., Toyama, R., Scita, G., DeLuca, L.M., Taira, M., Levin, A.A., Ozato, K., and Dawid, I.B. (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc. Natl. Acad. Sci. USA. 93:1803-1807
Appel, B., Korzh, V., Glasgow, E., Thor, S., Edlund, T., Dawid, I.B., and Eisen, J.S. (1995) Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development (Cambridge, England). 121:4117-4125
Toyama, R., Curtiss, P.E., Otani, H., Kimura, M., Dawid, I.B., and Taira, M. (1995) The LIM class homeobox gene lim5: implied role in CNS patterning in Xenopus and zebrafish. Developmental Biology. 170:583-593
Toyama, R., O'Connell, M.L., Wright, C.V.E., Kuehn, M.R., and Dawid, I.B. (1995) Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development (Cambridge, England). 121:383-391
Mahon, K.A. and Dawid, I.B. (1992) Development shows some backbone. HFSP Workshop on Genetic Control of Vertebrate Development cosponsored by the Human Frontier Science Program, European Science Foundation, and European Molecular Biology Organization, Les Diablerets, Switzerland, May 26-30, 1991. New. Biol.. 4(1):36-41