Gene
wnt11f2
- ID
- ZDB-GENE-990603-12
- Name
- wnt 11, family member 2
- Symbol
- wnt11f2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Acts upstream of or within several processes, including Kupffer's vesicle development; embryonic morphogenesis; and negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. Is expressed in several structures, including EVL; head; mesoderm; musculature system; and tail bud. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11).
- Genome Resources
- Note
-
Once thought to be the ortholog of human WNT11, the relationship of this wnt gene was clarified in Postlethwait et al. 2019. Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes. Zebrafish 16(5):469-476.
- Comparative Information
-
- All Expression Data
- 45 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb748 (64 images)
- eu266 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 46 figures from 33 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| tx226 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tz216 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| u148 | unknown | Unknown | Unknown | not specified | |
| wnt11f2_unspecified | Unspecified Allele | Unknown | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-wnt11f2 | N/A | (23) |
| MO2-wnt11f2 | N/A | (10) |
| MO3-wnt11f2 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|
|
UniProtKB:A0A8M3B2Q8
|
353 | |||
|
UniProtKB:B8JM95
|
353 | |||
|
UniProtKB:O73864
|
354 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:wnt11f2-IRES-Tomato,cryaa:EGFP) |
| 1 | Jussila et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-223D24 | ZFIN Curated Data | |
| Contains | SNP | rs3727880 | Stickney et al., 2002 | |
| Encodes | EST | cb748 | Thisse et al., 2001 | |
| Encodes | EST | eu266 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193977 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144804 (1) | 2132 nt | ||
| Genomic | GenBank:CU571324 (1) | 78830 nt | ||
| Polypeptide | UniProtKB:O73864 (1) | 354 aa |
No data available
- Hadzhiev, Y., Wheatley, L., Cooper, L., Ansaloni, F., Whalley, C., Chen, Z., Finaurini, S., Gustincich, S., Sanges, R., Burgess, S., Beggs, A., Müller, F. (2023) The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation. Developmental Cell. 58:155170.e8155-170.e8
- McLeod, J.J., Rothschild, S.C., Francescatto, L., Kim, H., Tombes, R.M. (2023) Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):390-403
- De Jong, H.N., Dewey, F.E., Cordero, P., Victorio, R.A., Kirillova, A., Huang, Y., Madhvani, R., Seo, K., Werdich, A.A., Lan, F., Orcholski, M., Robert Liu, W., Erbilgin, A., Wheeler, M.T., Chen, R., Pan, S., Kim, Y.M., Bommakanti, K., Marcou, C.A., Martijn Bos, J., Haddad, F., Ackerman, M., Vasan, R.S., MacRae, C., Wu, J.C., de Jesus Perez, V., Snyder, M., Parikh, V.N., Ashley, E.A. (2022) Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circulation. Genomic and precision medicine. 15(4):e003563
- Jussila, M., Boswell, C.W., Griffiths, N.W., Pumputis, P.G., Ciruna, B. (2022) Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2. Nature communications. 13:5598
- Naraine, R., Iegorova, V., Abaffy, P., Franek, R., Soukup, V., Psenicka, M., Sindelka, R. (2022) Evolutionary conservation of maternal RNA localization in fishes and amphibians revealed by TOMO-Seq. Developmental Biology. 489:146-160
- Hu, B., Rodriguez, J.J., Kakkerla Balaraju, A., Gao, Y., Nguyen, N.T., Steen, H., Suhaib, S., Chen, S., Lin, F. (2021) Glypican 4 mediates Wnt transport between germ layers via signaling filopodia. The Journal of cell biology. 220(12):
- Petridou, N.I., Corominas-Murtra, B., Heisenberg, C.P., Hannezo, E. (2021) Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7):1914-1928.e19
- Xia, Z.J., Zeng, X.I., Tambe, M., Ng, B.G., Dong, P.D.S., Freeze, H.H. (2021) A Dominant Heterozygous Mutation in COG4 Causes Saul-Wilson Syndrome, a Primordial Dwarfism, and Disrupts Zebrafish Development via Wnt Signaling. Frontiers in cell and developmental biology. 9:720688
- Fulton, T., Trivedi, V., Attardi, A., Anlas, K., Dingare, C., Arias, A.M., Steventon, B. (2020) Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis. Current biology : CB. 30(15):2984-2994.e3
- Lee, Y.H., Kawakami, K., HuangFu, W.C., Liu, I.H. (2020) Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway. PLoS One. 15:e0230943
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