Research
General Information
ZIRC
ZFIN: Gene: fgf8a
ZFIN ID: ZDB-GENE-990415-72

Gene Name:fibroblast growth factor 8 a
Gene Symbol: fgf8a
Previous Names: wu:fb73a06, acerebellar, ace, fgf-8, cb110(1) , id:ibd5031, etID309886.13(1) , fgf8
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 176 figure(s) from 140 publications
Directly submitted expression data: 7 figure(s) (100 images) from Thisse et al., 2001 [cb110]
  4 figure(s) (5 images) from Kudoh et al., 2001 [ibd5031]
Wild Type Stages, Structures: Cleavage:8-cell (1.25h-1.50h) to Adult (90d-730d, breeding adult)
  apical ectodermal ridge pectoral fin bud, axial mesoderm ... (all 106)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   24 genotypes
Allele(s):   ti282a, unspecified_fgf8a
Phenotype: (current status)
  Data: 27 figures from 18 publications
  Observed in: alar plate midbrain region, anatomical system, apoptosis, atrium, blood circulation ... (all 50)
Knockdown reagents: MO1-fgf8a (1) ,   MO2-fgf8a (1) ,   MO3-fgf8a (1) ,   MO4-fgf8a (1) ,   MO5-fgf8a (1)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Biological Process determination of dorsal identity (more)
Cellular Component extracellular space (more)
Molecular Function growth factor activity
All GO Terms (49)

Protein Families, Domains and Sites:
  • InterPro:IPR002348 (1)
  • InterPro:IPR008996 (1)
  • PROSITE:PS00247 (1)
  • Pfam:PF00167 (1)
  • Loading Transcript Data...

    CONSTRUCTS WITH SEQUENCE FROM fgf8a:
    Tg(fgf8a.1:EGFP), Tg(hsp70l:fgf8a), Tg(fgf8a.2:EGFP)

    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    fgf8a Contained in [BAC] CH211-194I8 (1)    (order this)
    fgf8a Encodes [EST] cb110 (1)    (order this) , fb73a06 (1) , ibd5031 (1)    (order this)
    [cDNA] MGC:101652 (1)    (order this) , MGC:192193 (1)    (order this)

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131281 (1) 2146 bp
    Genomic GenBank:CR925797 (1) 65727 bp
    Polypeptide UniProtKB:O42278 (1) 210 aa
    Sequence Clusters UniGene:478 (1)
    All Sequence Information (19)

    OTHER  fgf8a  GENE / MARKER PAGES:

  • Entrez Gene:30538 (1)
  • VEGA:OTTDARG00000018834 (1)
  • Ensembl(Zv8):ENSDARG00000003399 (1)

  • MAPPING INFORMATION:
      LG:  13 ,  23  Details   View Map: Merged  Individual Panels

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish fgf8a  13 ,  23
    Human FGF8  10 (q24)
  • OMIM:600483
  • Entrez Gene:2253
  • Mouse Fgf8  19 (45.00 cM)
  • MGI:99604
  • Entrez Gene:14179
  • Orthology Details
    Orthology Note
    x

    Orthology Note for fgf8a

    This is a note


    CITATIONS   (283)