Gene
sod1
- ID
- ZDB-GENE-990415-258
- Name
- superoxide dismutase 1, soluble
- Symbol
- sod1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables superoxide dismutase activity. Acts upstream of or within several processes, including neuron cellular homeostasis; response to metal ion; and response to methylmercury. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including cytosol; mitochondrion; and peroxisome. Is expressed in several structures, including blastoderm; cardiovascular system; eye; head mesenchyme; and musculature system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 57 figures from 47 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137288 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sod1 | Zhou et al., 2018 | |
| CRISPR2-sod1 | Zhou et al., 2018 | |
| CRISPR3-sod1 | Zebrafish Nomenclature Committee | |
| MO1-sod1 | N/A | Kabashi et al., 2011 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | Alliance | Amyotrophic lateral sclerosis 1 | 105400 |
| Spastic tetraplegia and axial hypotonia, progressive | 618598 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| amyotrophic lateral sclerosis | sod1zf503/zf503 | standard conditions | Da Costa et al., 2014 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018152 | Superoxide dismutase, copper/zinc, binding site |
| Domain | IPR001424 | Superoxide dismutase, copper/zinc binding domain |
| Family | IPR024134 | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone |
| Homologous_superfamily | IPR036423 | Superoxide dismutase-like, copper/zinc binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Superoxide dismutase, copper/zinc binding domain | Superoxide dismutase, copper/zinc, binding site | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone | Superoxide dismutase-like, copper/zinc binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:B2GRH9 | InterPro | 154 | ||||
| UniProtKB:O73872 | InterPro | 154 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-sod1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
5 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(sod1:sod1_G93R,hsp70l:DsRed) |
|
|
| 2 | (12) |
| Tg(sod1:sod1,hsp70l:DsRed) |
|
|
| 2 | (9) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-50P8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7137288 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66152 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192309 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131294 (1) | 761 nt | ||
| Genomic | GenBank:AL837524 (2) | 202158 nt | ||
| Polypeptide | UniProtKB:B2GRH9 (1) | 154 aa |
- Diana, A., Ghilardi, A., Del Giacco, L. (2024) Differentiation and functioning of the lateral line organ in zebrafish require Smpx activity. Scientific Reports. 14:78627862
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Wang, Y., Yuan, B., Liu, W., Cui, J., Zhou, X., Yuan, L., Deng, Z., Li, Y., Yuan, X. (2024) The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults. International Journal of Nanomedicine. 19:103871040010387-10400
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
- Zhou, R., Ding, R.C., Yu, Q., Qiu, C.Z., Zhang, H.Y., Yin, Z.J., Ren, D.L. (2024) Metformin Attenuates Neutrophil Recruitment through the H3K18 Lactylation/Reactive Oxygen Species Pathway in Zebrafish. Antioxidants (Basel, Switzerland). 13(2):
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Cao, P., Cheng, Y., Li, Z., Cheng, Y.J., Chu, X., Geng, C., Yin, X., Li, Y. (2023) Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration. Journal of nanobiotechnology. 21:4444
- Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310
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