ZFIN ID: ZDB-GENE-990415-258
Gene Name: superoxide dismutase 1, soluble
Gene Symbol: sod1    Nomenclature History

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Previous Names: ZSOD (1), Cu/Zn-SOD (1), cuzn, sod(Cu/Zn) (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits superoxide dismutase activity. Involved in several processes, including neuron cellular homeostasis; response to metal ion; and response to methylmercury. Predicted to localize to the cytosol; mitochondrion; and nucleus. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Is expressed in several structures, including blastoderm; blastodisc; liver; musculature system; and nervous system. Orthologous to human SOD1 (superoxide dismutase 1).
Genome Resources: Alliance (1),  Gene:30553 (1),  Ensembl(GRCz11):ENSDARG00000043848 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zf503 Unknown Unknown Unknown ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-sod1
1
CRISPR2-sod1
1
MO1-sod1 N/A 1
PHENOTYPE
Data: 2 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH sod1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 1 Alliance Amyotrophic lateral sclerosis 1 105400
Spastic tetraplegia and axial hypotonia, progressive 618598
DISEASE ASSOCIATED WITH sod1 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
amyotrophic lateral sclerosis sod1zf503/zf503 standard conditions Da Costa et al., 2014
GENE ONTOLOGY
Ontology GO Term
Biological Process response to metal ion (more)
Cellular Component cytoplasm (more)
Molecular Function superoxide dismutase activity (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Binding_site IPR018152 Superoxide dismutase, copper/zinc, binding site
Domain IPR001424 Superoxide dismutase, copper/zinc binding domain
Family IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
Homologous_superfamily IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sod1-201 (1)    Ensembl 773
ncRNA sod1-002 (1)    Ensembl 644
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-sod1 polyclonal IgG Rabbit WB Santa Cruz Biotechnology, Inc.
4
CONSTRUCTS WITH SEQUENCES FROM sod1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(sod1:sod1,hsp70l:DsRed) hsp70lsod1 DsRedsod1 Danio rerio 2 7
Tg(sod1:sod1_G93R,hsp70l:DsRed) hsp70lsod1 DsRedsod1 Danio rerio 2 9
MARKER RELATIONSHIPS
sod1 Contained in: [BAC] DKEY-50P8 (1) (order this)
sod1 Encodes: [EST] IMAGE:7137288 (1)
[cDNA] MGC:66152 (1), MGC:192309 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131294 (1) 761 nt
Genomic GenBank:AL837524 (1) 202158 nt Blast at MegaBLAST
Polypeptide UniProtKB:B2GRH9 (1) 154 aa
Sequence Information (all 17)
ORTHOLOGY for sod1 ( Chr: 10 )
CITATIONS (275)