Gene
sod1
- ID
- ZDB-GENE-990415-258
- Name
- superoxide dismutase 1, soluble
- Symbol
- sod1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits superoxide dismutase activity. Involved in several processes, including neuron cellular homeostasis; response to metal ion; and response to methylmercury. Predicted to localize to several cellular components, including extracellular space; mitochondrion; and peroxisome. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Is expressed in several structures, including blastoderm; blastodisc; liver; musculature system; and nervous system. Orthologous to human SOD1 (superoxide dismutase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 54 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137288 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | Alliance | Amyotrophic lateral sclerosis 1 | 105400 |
| Spastic tetraplegia and axial hypotonia, progressive | 618598 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| amyotrophic lateral sclerosis | sod1zf503/zf503 | standard conditions | Da Costa et al., 2014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018152 | Superoxide dismutase, copper/zinc, binding site |
| Domain | IPR001424 | Superoxide dismutase, copper/zinc binding domain |
| Family | IPR024134 | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone |
| Homologous_superfamily | IPR036423 | Superoxide dismutase-like, copper/zinc binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Superoxide dismutase, copper/zinc binding domain | Superoxide dismutase, copper/zinc, binding site | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone | Superoxide dismutase-like, copper/zinc binding domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B2GRH9
|
154 | ||||
|
UniProtKB:O73872
|
154 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-sod1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
5 |
Plasmids