ZFIN is now using GRCz12tu for Genomic Data
Gene
rrm1
- ID
- ZDB-GENE-990415-247
- Name
- ribonucleotide reductase M1 polypeptide
- Symbol
- rrm1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in DNA synthesis involved in DNA repair and deoxyribonucleotide biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including immature eye; nervous system; neural tube; presumptive telencephalon; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 6. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb396 (13 images)
- cb548 (24 images)
- cb838 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 6 | Alliance | Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 | 620647 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000788 | Ribonucleotide reductase large subunit, C-terminal |
| Domain | IPR005144 | ATP-cone domain |
| Domain | IPR013346 | Ribonucleotide reductase, class I, alpha subunit, C-terminal |
| Domain | IPR013509 | Ribonucleotide reductase large subunit, N-terminal |
| Family | IPR039718 | Ribonucleoside-diphosphate reductase large subunit |
| Homologous_superfamily | IPR008926 | Ribonucleotide reductase R1 subunit, N-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-cone domain | Ribonucleoside-diphosphate reductase large subunit | Ribonucleotide reductase, class I, alpha subunit, C-terminal | Ribonucleotide reductase large subunit, C-terminal | Ribonucleotide reductase large subunit, N-terminal | Ribonucleotide reductase R1 subunit, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:P79732 | InterPro | 794 | ||||||
| UniProtKB:F1R2K9 | InterPro | 794 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers