Gene
hbae1.1
- ID
- ZDB-GENE-980526-80
- Name
- hemoglobin, alpha embryonic 1.1
- Symbol
- hbae1.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to act upstream of or within oxygen transport. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA1 (hemoglobin subunit alpha 1) and HBZ (hemoglobin subunit zeta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 122 figures from 80 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alpha thalassemia | Alliance | Thalassemias, alpha- | 604131 |
| familial erythrocytosis 7 | Alliance | Erythrocytosis, familial, 7 | 617981 |
| Heinz body anemia | Alliance | Heinz body anemias, alpha- | 140700 |
| hemoglobin H disease | Alliance | Hemoglobin H disease, nondeletional | 613978 |
| Methemoglobinemia, alpha type | 617973 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin, alpha-type | Hemoglobin and related oxygen transporters | Hemoglobin, pi |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZT21 | InterPro | 143 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | hbae1-001 (1) | Havana | 877 nt | ||
| mRNA |
hbae1.1-201
(1)
|
Ensembl | 633 nt | ||
| mRNA | ottdart00000002407 (1) | Havana | 555 nt | ||
| mRNA | ottdart00000002419 (1) | Havana | 838 nt |
Interactions and Pathways
No data available
Plasmids
No data available