Gene
wnt1
- ID
- ZDB-GENE-980526-526
- Name
- wingless-type MMTV integration site family, member 1
- Symbol
- wnt1 Nomenclature History
- Previous Names
-
- int-1
- etID22400.23 (1)
- sb:eu647
- zgc:194464
- zgc:194478
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within brain development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 116 figures from 83 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu647 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wnt1 | Kesavan et al., 2020 | |
| MO1-wnt1 | N/A | (4) |
| MO2-wnt1 | N/A | (3) |
| MO3-wnt1 | N/A | Houart et al., 2002 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 15 | Alliance | Osteogenesis imperfecta, type XV | 615220 |
| {Osteoporosis, early-onset, susceptibility to, autosomal dominant} | 615221 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt-1 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B987 | InterPro | 375 | ||||
| UniProtKB:B3DI55 | InterPro | 370 | ||||
| UniProtKB:P24257 | InterPro | 370 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-6.6wnt1:GAL4-VP16-6.7wnt1,14xUAS-E1B:EGFP) |
|
| 1 | (5) | |
| Tg(wnt1:EGFP) |
|
| 1 | Gibbs et al., 2014 | |
| Tg(wnt1:Venus) |
|
| 1 | Kesavan et al., 2020 | |
| Tg(wnt1:Venus-NLS) |
|
| 1 | Kesavan et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-166N8 | ZFIN Curated Data | |
| Encodes | EST | eu647 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194464 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194478 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001201398 (1) | 1360 nt | ||
| Genomic | GenBank:CR352210 (1) | 180924 nt | ||
| Polypeptide | UniProtKB:A0A8M2B987 (1) | 375 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Maekawa, M., Saito, S., Isobe, D., Takemoto, K., Miura, Y., Dobashi, Y., Yamasu, K. (2024) The Oct4-related PouV gene, pou5f3, mediates isthmus development in zebrafish by directly and dynamically regulating pax2a. Cells & development. 179:203933
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Xiao, Y., Hu, M., Lin, Q., Zhang, T., Li, S., Shu, L., Song, X., Xu, X., Meng, W., Li, X., Xu, H., Mo, X. (2023) Dopey2 and Pcdh7 orchestrate the development of embryonic neural stem cells/ progenitors in zebrafish. iScience. 26:106273106273
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- Marcogliese, P.C., Dutta, D., Ray, S.S., Dang, N.D.P., Zuo, Z., Wang, Y., Lu, D., Fazal, F., Ravenscroft, T.A., Chung, H., Kanca, O., Wan, J., Douine, E.D., Network, U.D., Pena, L.D.M., Yamamoto, S., Nelson, S.F., Might, M., Meyer, K.C., Yeo, N.C., Bellen, H.J. (2022) Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Science advances. 8:eabl5613
- Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Zhou, J., Yang, Y.J., Gan, R.H., Wang, Y., Li, Z., Zhang, X.J., Gui, J.F., Zhou, L. (2022) Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. Gene expression patterns : GEP. 46:119286
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