ZFIN ID: ZDB-GENE-980526-526

Gene Name:wingless-type MMTV integration site family, member 1
Gene Symbol: wnt1

Previous Names: sb:eu647, zgc:194478, zgc:194464, int-1, etID22400.23(1)
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	52 figure(s) from 35 publications
Directly submitted expression data:	6 figure(s) (26 images) from Thisse et al., 2005 [eu647]
Wild Type Stages, Structures:	Gastrula:Shield (6.00h-8.00h) to Adult (90d-730d, breeding adult)
	alar plate midbrain region, cerebellum ... (all 32)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   3 genotypes
Allele(s):   Df(LG23:acvr1b,sp5l,wnt1,wnt10b)w5

Phenotype: (current status)

Data:	1 figure from Elsen et al., 2008
Observed in:	fourth ventricle, fourth ventricle development

Knockdown reagents: MO1-wnt1 (1) ,   MO2-wnt1 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Molecular Function	signal transducer activity
Biological Process	midbrain-hindbrain boundary development (more)
Cellular Component	extracellular region (more)

All GO Terms (13)

Protein Families, Domains and Sites:

InterPro:IPR005816 (1) InterPro:IPR005817 (1) InterPro:IPR009139 (1) InterPro:IPR018161 (1)

PROSITE:PS00246 (1)

Pfam:PF00110 (1)

Gene Product Description

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

wnt1 Contained in	[BAC] DKEY-166N8 (1)    (order this)
wnt1 Encodes	[EST] eu647 (1) [cDNA] MGC:194464 (1)    (order this) , MGC:194478 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_130951 (1)	1113 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR352210 (1)	180924 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:B3DI55 (1)	370 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:85371 (1)
All Sequence Information (17)

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OTHER  wnt1  GENE / MARKER PAGES:

Entrez Gene:30128 (1)

VEGA:OTTDARG00000028143 (1)

Ensembl(Zv8):ENSDARG00000055554 (1)

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MAPPING INFORMATION:

LG:  23  Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	wnt1	23
Human	WNT1	12 (q13)	OMIM:164820 Entrez Gene:7471
Mouse	Wnt1	15 (56.80 cM)	MGI:98953 Entrez Gene:22408
Orthology Details

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CITATIONS   (70)