Gene
nkx2.2a
- ID
- ZDB-GENE-980526-403
- Name
- NK2 homeobox 2a
- Symbol
- nkx2.2a Nomenclature History
- Previous Names
-
- nk2.2
- nkx2-2
- nkx2.2
- id:ibd5090 (1)
- wu:fc83b01
- zgc:136536
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within endocrine pancreas development; floor plate formation; and neurogenesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; neural keel; neural rod; and neural tube. Orthologous to human NKX2-2 (NK2 homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 153 figures from 98 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912071 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23158 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nkx2.2a | N/A | Schafer et al., 2007 |
| MO2-nkx2.2a | N/A | Pauls et al., 2007 |
| MO3-nkx2.2a | N/A | (3) |
| MO4-nkx2.2a | N/A | (4) |
| MO5-nkx2.2a | N/A | (2) |
| MO6-nkx2.2a | N/A | Anderson et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|
|
UniProtKB:Q90481
|
269 | |||||
|
UniProtKB:F1QNE4
|
273 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nkx2.2a-201
(1)
|
Ensembl | 1,555 nt | ||
| mRNA |
nkx2.2a-202
(1)
|
Ensembl | 1,730 nt | ||
| mRNA |
nkx2.2a-203
(1)
|
Ensembl | 4,321 nt | ||
| mRNA |
nkx2.2a-204
(1)
|
Ensembl | 4,557 nt | ||
| mRNA |
nkx2.2a-205
(1)
|
Ensembl | 1,550 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-3.5nkx2.2a:GFP) |
|
| 1 | (16) | |
| Tg(nkx2.2a:mEGFP) |
|
| 2 | (76) | |
| Tg(-3.5nkx2.2a:Cre,myl7:EGFP) |
|
| 1 | Fontenas et al., 2021 | |
| Tg(-3.5nkx2.2a:mCerulean) |
|
| 1 | Fontenas et al., 2021 | |
| Tg(-3.5nkx2.2a:NLS-EGFP) |
|
| 1 | (2) | |
| Tg(-3.5nkx2.2a:NLS-mCherry) |
|
| 2 | (4) | |
| Tg(-8.5nkx2.2a:GFP) |
|
| 1 | (7) | |
| Tg(nkx2.2a:GAL4-VP16,myl7:EGFP) |
|
| 1 | Arena et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-89L19 | ZFIN Curated Data | |
| Encodes | EST | fc83b01 | ZFIN Curated Data | |
| Encodes | EST | ibd5090 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6912071 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100783 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136536 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001308640 (1) | 1733 nt | ||
| Genomic | GenBank:BX927409 (2) | 154287 nt | ||
| Polypeptide | UniProtKB:F1QNE4 (1) | 273 aa |
- Burkhalter, M.D., Stiff, T., Maerz, L.D., Casar Tena, T., Wiese, H., Gerhards, J., Sailer, S.A., Vu, L.A.T., Duong Phu, M., Donow, C., Alupei, M., Iben, S., Groth, M., Wiese, S., Church, J.A., Jeggo, P.A., Philipp, M. (2024) Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Cell Death & Disease. 15:660660
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Gerhards, J., Maerz, L.D., Matthees, E.S.F., Donow, C., Moepps, B., Premont, R.T., Burkhalter, M.D., Hoffmann, C., Philipp, M. (2023) Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development. Journal of the American Society of Nephrology : JASN. 34(4):590-606
- Arena, K.A., Zhu, Y., Kucenas, S. (2022) Transforming growth factor-beta signaling modulates perineurial glial bridging following peripheral spinal motor nerve injury in zebrafish. Glia. 70(10):1826-1849
- Brożko, N., Baggio, S., Lipiec, M.A., Jankowska, M., Szewczyk, Ł.M., Gabriel, M.O., Chakraborty, C., Ferran, J.L., Wiśniewska, M.B. (2022) Genoarchitecture of the Early Postmitotic Pretectum and the Role of Wnt Signaling in Shaping Pretectal Neurochemical Anatomy in Zebrafish. Frontiers in Neuroanatomy. 16:838567
- Carril Pardo, C.A., Massoz, L., Dupont, M.A., Bergemann, D., Bourdouxhe, J., Lavergne, A., Tarifeño-Saldivia, E., Helker, C.S., Stainier, D.Y., Peers, B., Voz, M.M., Manfroid, I. (2022) A δ-cell subpopulation with pro-β cell identity contributes to efficient age-independent recovery in a zebrafish diabetes model. eLIFE. 11:
- Jacobs, C.T., Kejriwal, A., Kocha, K.M., Jin, K.Y., Huang, P. (2022) Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. Developmental Biology. 489:1-13
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Vasileva, E., Warren, M., Triche, T.J., Amatruda, J.F. (2022) Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth. eLIFE. 11:
- Fontenas, L., Kucenas, S. (2021) Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia. eLIFE. 10:
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