Gene
ins
- ID
- ZDB-GENE-980526-110
- Name
- preproinsulin
- Symbol
- ins Nomenclature History
- Previous Names
-
- insa (1)
- zgc:109842
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 346 figures from 208 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109842 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ins | (4) | |
| CRISPR2-ins | Zebrafish Nomenclature Committee | |
| MO1-ins | N/A | Shimada et al., 2012 |
| MO2-ins | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| maturity-onset diabetes of the young type 10 | Alliance | Maturity-onset diabetes of the young, type 10 | 613370 |
| type 1 diabetes mellitus 2 | Alliance | Diabetes mellitus, insulin-dependent, 2 | 125852 |
| Diabetes mellitus, permanent neonatal 4 | 618858 | ||
| Hyperproinsulinemia | 616214 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin | Insulin, conserved site | Insulin family | Insulin-like | Insulin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B2GSI0 | InterPro | 108 | |||||
| UniProtKB:O73727 | InterPro | 108 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.0ins:EGFP) |
|
| 1 | (32) | |
| Tg(ins:CFP-NTR) |
|
| 1 | (31) | |
| Tg(-1.0ins:GCaMP6s,myl7:EGFP) |
|
| 1 | (2) | |
| Tg(-1.0ins:Hsa.INS_C43G-GFP) |
|
| 1 | (5) | |
| Tg(-1.0ins:Hsa.INS-GFP) |
|
| 1 | (4) | |
| Tg(-1.0ins:LOXP-mCherry-LOXP-caMmu.Kcnj11,myl7:EGFP) |
|
| 1 | Emfinger et al., 2019 | |
| Tg1(-1.5ins:Hsa.INS-EGFP,-.58cryaa:Cerulean) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(-1.2ins:EGFP) |
|
| 1 | (5) | |
| Tg(-1.2ins:Hsa.FGF1,myl7:EGFP) |
|
| 1 | Li et al., 2016 | |
| Tg(-1.2ins:Hsa.GCK_V91L,cryaa:TagRFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69I14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-139A5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109842 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192614 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131056 (1) | 468 nt | ||
| Genomic | GenBank:AL935065 | 167740 nt | ||
| Polypeptide | UniProtKB:B2GSI0 (1) | 108 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Burkhalter, M.D., Stiff, T., Maerz, L.D., Casar Tena, T., Wiese, H., Gerhards, J., Sailer, S.A., Vu, L.A.T., Duong Phu, M., Donow, C., Alupei, M., Iben, S., Groth, M., Wiese, S., Church, J.A., Jeggo, P.A., Philipp, M. (2024) Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Cell Death & Disease. 15:660660
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Kaplan, G., Beler, M., Ünal, I., Karagöz, A., Eğilmezer, G., Üstündağ, Ü.V., Cansız, D., Alturfan, A.A., Emekli-Alturfan, E. (2024) Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos. Toxicology and industrial health. 40(5):232-243
- Lee, D.W., Park, H.C., Kim, D.H. (2024) Transgenic zebrafish as a model for investigating diabetic peripheral neuropathy: investigation of the role of insulin signaling. Frontiers in Cellular Neuroscience. 18:14418271441827
- Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R. (2024) ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(9):934-946
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Yu, W., Luo, R., He, C., Li, Z., Yang, M., Zhou, J., He, J., Chen, Q., Song, Z., Cheng, S. (2024) Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models. Frontiers in pharmacology. 15:13391781339178
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
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