Gene

mcf2l2

ID

ZDB-GENE-100812-1

Name

MCF.2 cell line derived transforming sequence-like 2

Symbol

mcf2l2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction. Orthologous to human MCF2L2 (MCF.2 cell line derived transforming sequence-like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcf2l2 Human Ortholog

No data available

Associated With mcf2l2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR035532	DBS, SH3 domain
Domain	IPR035534	DBS, PH domain
Family	IPR051336	Rho GTPase-activating Guanine Nucleotide Exchange Factors
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily
Repeat	IPR018159	Spectrin/alpha-actinin

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	CRAL-TRIO lipid binding domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	DBS, PH domain	DBS, SH3 domain	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	Rho GTPase-activating Guanine Nucleotide Exchange Factors	SH3 domain	SH3-like domain superfamily	Spectrin/alpha-actinin
UniProtKB:A0A8M9QLV2 InterPro	1160
UniProtKB:A0A8M9QHY0 InterPro	1283
UniProtKB:A0A8M3AXG6 InterPro	1259
UniProtKB:A0A8M9Q7I6 InterPro	1274
UniProtKB:A0A8M3AXE9 InterPro	1229
UniProtKB:A0A8M9QDF3 InterPro	1221
UniProtKB:A0A8M9PV88 InterPro	1282
UniProtKB:A0A8M9QLU9 InterPro	1284
UniProtKB:A0A8M3BDJ3 InterPro	1237

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mcf2l2-201 (1) Ensembl	Ensembl	4,252 nt	Select Tool ZFIN BLAST
mRNA	mcf2l2-202 (1) Ensembl	Ensembl	6,479 nt	Select Tool
mRNA	mcf2l2-203 (1) Ensembl	Ensembl	4,333 nt	Select Tool ZFIN BLAST
mRNA	mcf2l2-204 (1) Ensembl	Ensembl	3,841 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations