Gene
palb2
- ID
- ZDB-GENE-090313-43
- Name
- partner and localizer of BRCA2
- Symbol
- palb2 Nomenclature History
- Previous Names
-
- fancn (1)
- Fanconi anemia, complementation group N
- si:ch211-14k19.9
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; breast cancer; and pancreatic cancer. Is expressed in brain; eye; immature eye; lens; and pectoral fin fold. Orthologous to human PALB2 (partner and localizer of BRCA2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Titus et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group N | Alliance | Fanconi anemia, complementation group N | 610832 |
| {Breast-ovarian cancer, familial, susceptibility to, 5} | 620442 | ||
| {Pancreatic cancer, susceptibility to, 3} | 613348 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Partner and localiser of BRCA2, WD40 domain | Partner and localizer of BRCA2 | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QKC3
|
1294 | ||||
|
UniProtKB:A0A8M9P7S0
|
1275 |
Interactions and Pathways
No data available
Plasmids
No data available