Gene

ifih1

ID

ZDB-GENE-081104-438

Name

interferon induced with helicase C domain 1

Symbol

ifih1 Nomenclature History

Previous Names

mda5 (1)
si:dkey-81j5.2

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity. Involved in regulation of transcription, DNA-templated. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human IFIH1 (interferon induced with helicase C domain 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ifih1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Aicardi-Goutieres syndrome	Alliance	Aicardi-Goutieres syndrome 7	615846
		Immunodeficiency 95	619773
		Singleton-Merten syndrome 1	182250

Associated With ifih1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR006935	Helicase/UvrB, N-terminal
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR021673	RIG-I-like receptor, C-terminal regulatory domain
Domain	IPR031964	Caspase recruitment domain
Domain	IPR041204	RIG-I-like receptor, C-terminal
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR038557	RIG-I-like receptor, C-terminal domain superfamily