Gene

ifih1

ID
ZDB-GENE-081104-438
Name
interferon induced with helicase C domain 1
Symbol
ifih1 Nomenclature History
Previous Names
  • mda5 (1)
  • si:dkey-81j5.2
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Involved in regulation of transcription, DNA-templated. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human IFIH1 (interferon induced with helicase C domain 1).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ifih1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Aicardi-Goutieres syndrome Alliance Aicardi-Goutieres syndrome 7 615846
Singleton-Merten syndrome 1 182250
Associated With ifih1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001650 Helicase, C-terminal
Domain IPR006935 Helicase/UvrB, N-terminal
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR021673 RIG-I-like receptor, C-terminal regulatory domain
Domain IPR031964 Caspase recruitment domain
Domain IPR041204 RIG-I receptor, C-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR038557 RIG-I-like receptor, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Caspase recruitment domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain Helicase/UvrB, N-terminal P-loop containing nucleoside triphosphate hydrolase RIG-I-like receptor, C-terminal domain superfamily RIG-I-like receptor, C-terminal regulatory domain RIG-I receptor, C-terminal
UniProtKB:F1R4B9 997
UniProtKB:A0A0K0K5Q0 685
UniProtKB:B0R1C5 704
UniProtKB:A0A0E3D804 997
UniProtKB:A0A2R8QBG0 685
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ifih1 polyclonal Rabbit
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations