kdm2bb

ID

ZDB-GENE-080225-13

Name

lysine (K)-specific demethylase 2Bb

Symbol

kdm2bb Nomenclature History

Previous Names

jhdm1B (1)
fbxl10 (1)
im:7154787

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA binding activity; histone H3K36me/H3K36me2 demethylase activity; and zinc ion binding activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; hematopoietic progenitor cell differentiation; and rRNA transcription. Predicted to be located in chromosome and nucleolus. Is expressed in central nervous system and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities. Orthologous to human KDM2B (lysine demethylase 2B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7154787 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm2bb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities	Alliance	Neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities	621474

Associated With kdm2bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Domain	IPR002857	Zinc finger, CXXC-type
Domain	IPR003347	JmjC domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR041070	Jumonji, helical domain
Domain	IPR041667	Cupin-like domain 8
Domain	IPR057207	F-box/LRR-repeat protein 15-like, leucin rich repeat domain
Family	IPR050690	JHDM1 Histone Demethylase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR006553	Leucine-rich repeat, cysteine-containing subtype

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B6L0	InterPro	778
UniProtKB:A0A8M9PAJ6	InterPro	513
UniProtKB:A0A8M9PLZ6	InterPro	313
UniProtKB:A0AB32TVL5	InterPro	1263
UniProtKB:A0AB32TYW7	InterPro	1063
UniProtKB:F6P9Q3	InterPro	1260
UniProtKB:A0AC58GID1	InterPro	1246
UniProtKB:A0AC58GID4	InterPro	1243
UniProtKB:A0AC58GII6	InterPro	1253
UniProtKB:A0AC58GIK5	InterPro	1060
UniProtKB:A0AC58GIM7	InterPro	778
UniProtKB:A0AC58GIN6	InterPro	775