Gene
wdfy3
- ID
- ZDB-GENE-070705-153
- Name
- WD repeat and FYVE domain containing 3
- Symbol
- wdfy3 Nomenclature History
- Previous Names
-
- si:ch211-259k10.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to be involved in aggrephagy. Human ortholog(s) of this gene implicated in primary autosomal dominant microcephaly 18. Orthologous to human WDFY3 (WD repeat and FYVE domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal dominant microcephaly 18 | Alliance | ?Microcephaly 18, primary, autosomal dominant | 617520 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR000306 | FYVE zinc finger |
| Domain | IPR000409 | BEACH domain |
| Domain | IPR017455 | Zinc finger, FYVE-related |
| Domain | IPR023362 | PH-BEACH domain |
| Family | IPR051944 | BEACH domain-containing protein |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036372 | BEACH domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | BEACH domain | BEACH domain-containing protein | BEACH domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | FYVE zinc finger | PH-BEACH domain | PH-like domain superfamily | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, FYVE-related | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BCS8
|
3525 | ||||||||||||||||
|
UniProtKB:A0A8M6Z0T9
|
3496 | ||||||||||||||||
|
UniProtKB:A0A8M6YZB2
|
3497 | ||||||||||||||||
|
UniProtKB:A0A8M6Z6H7
|
3523 | ||||||||||||||||
|
UniProtKB:A0A8M1QLH0
|
3505 | ||||||||||||||||
|
UniProtKB:A0A8M9PYD4
|
113 | ||||||||||||||||
|
UniProtKB:A0A8M6YYF4
|
3524 |
Interactions and Pathways
No data available
Plasmids
No data available