Gene

lyst

ID

ZDB-GENE-070702-1

Name

lysosomal trafficking regulator

Symbol

lyst Nomenclature History

Previous Names

si:ch211-30i2.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to act upstream of or within lysosome organization. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Kim et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lyst Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Chediak-Higashi syndrome	Alliance	Chediak-Higashi syndrome	214500

Associated With lyst Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR000409	BEACH domain
Domain	IPR023362	PH-BEACH domain
Family	IPR050865	BEACH Domain-Containing
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036372	BEACH domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	BEACH domain	BEACH Domain-Containing	BEACH domain superfamily	PH-BEACH domain	PH-like domain superfamily	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M6Z3Z4 InterPro	3826
UniProtKB:A0A8M6Z2E9 InterPro	3886
UniProtKB:A0A8M9PU84 InterPro	3832
UniProtKB:A0A8M3AZH9 InterPro	3832

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	lyst-201 (1) Ensembl	Ensembl		8,001 nt	Select Tool ZFIN BLAST
mRNA	lyst-202 (1) Ensembl	Ensembl		7,983 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations