Gene

serpinf2b

ID

ZDB-GENE-061215-114

Name

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b

Symbol

serpinf2b Nomenclature History

Previous Names

zgc:158410

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in positive regulation of coagulation. Predicted to act upstream of or within negative regulation of fibrinolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With serpinf2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
alpha-2-plasmin inhibitor deficiency	Alliance	Alpha-2-plasmin inhibitor deficiency	262850

Associated With serpinf2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Domain	IPR033833	Alpha2-antiplasmin, serpin domain
Family	IPR000215	Serpin family
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2

Domain Details Per Protein

Protein	Length	Alpha2-antiplasmin, serpin domain	Serpin, conserved site	Serpin domain	Serpin family	Serpin superfamily	Serpin superfamily, domain 1	Serpin superfamily, domain 2
UniProtKB:A1A5Y8 InterPro	479

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	serpinf2b-201 (1) Ensembl	Ensembl	1,803 nt	Select Tool ZFIN BLAST
mRNA	serpinf2b-202 (1) Ensembl	Ensembl	623 nt	Select Tool ZFIN BLAST
mRNA	serpinf2b-203 (1) Ensembl	Ensembl	1,712 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations