Gene

dot1l

ID
ZDB-GENE-060503-341
Name
DOT1-like histone H3K79 methyltransferase
Symbol
dot1l Nomenclature History
Previous Names
  • si:dkey-211f22.1
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have histone methyltransferase activity (H3-K79 specific). Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Is expressed in hindbrain; intestine; and midbrain. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Mahmoudi et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dot1l Human Ortholog
No data available
Associated With dot1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations