Gene

cox5aa

ID

ZDB-GENE-050522-133

Name

cytochrome c oxidase subunit 5Aa

Symbol

cox5aa Nomenclature History

Previous Names

cox5a1 (1)
cox5a
cb739 (1)
wu:fj32b09
zgc:109989
zgc:114165

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Enables cytochrome-c oxidase activity. Acts upstream of or within embryonic organ development and spinal cord motor neuron differentiation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; musculature system; and nervous system. Used to study ciliopathy and visceral heterotaxy. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX5A (cytochrome c oxidase subunit 5A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb739 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cox5aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial complex IV deficiency nuclear type 20	Alliance	Mitochondrial complex IV deficiency, nuclear type 20	619064

Associated With cox5aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
visceral heterotaxy	WT + MO1-cox5aa	standard conditions	Burkhalter et al., 2019
ciliopathy	WT + MO1-cox5aa	standard conditions	Burkhalter et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR003204	Cytochrome c oxidase, subunit Va/VI
Homologous_superfamily	IPR036545	Cytochrome c oxidase, subunit Va/VI superfamily

Domain Details Per Protein

Protein	Length	Cytochrome c oxidase, subunit Va/VI	Cytochrome c oxidase, subunit Va/VI superfamily
UniProtKB:Q4VBU7 InterPro	141

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cox5aa-201 (1) Ensembl	Ensembl		690 nt	Select Tool ZFIN BLAST
mRNA	cox5aa-202 (1) Ensembl	Ensembl		457 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations