Gene

nop2

ID
ZDB-GENE-050309-7
Name
NOP2 nucleolar protein homolog (yeast)
Symbol
nop2 Nomenclature History
Previous Names
  • cb164 (1)
  • im:6893299 (1)
  • sb:cb164
  • si:dkey-91i17.1
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in maturation of LSU-rRNA and rRNA base methylation. Predicted to act upstream of or within RNA methylation; RNA processing; and ribosome biogenesis. Predicted to be active in nucleolus. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural tube; and pectoral fin. Orthologous to human NOP2 (NOP2 nucleolar protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa16537Allele with one point mutationUnknownMissense, Splice SiteENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
sa36089Allele with one point mutationUnknownSplice SiteENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With nop2 Human Ortholog
No data available
Associated With nop2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018314 RsmB/NOL1/NOP2-like, conserved site
Domain IPR001678 SAM-dependent methyltransferase RsmB-F/NOP2-type domain
Domain IPR011023 Nop2p
Domain IPR049560 SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
Domain IPR054728 Ribosomal RNA small subunit methyltransferase B-like, ferredoxin-like domain
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Domain Details Per Protein
Protein Additional Resources Length Nop2p Ribosomal RNA small subunit methyltransferase B-like, ferredoxin-like domain RNA (C5-cytosine) methyltransferase RNA (C5-cytosine) methyltransferase, NOP2 RsmB/NOL1/NOP2-like, conserved site S-adenosyl-L-methionine-dependent methyltransferase superfamily SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core SAM-dependent methyltransferase RsmB-F/NOP2-type domain
UniProtKB:A0A8M1P6F7 InterPro 739
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 16
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nop2-201 (1)
Ensembl
Ensembl 2,767 nt
ZFIN BLAST
ncRNA nop2-002 (1)
Ensembl
Ensembl 797 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-91I17ZFIN Curated Data
EncodesESTcb164Thisse et al., 2001
EncodesESTIMAGE:6893299Thisse et al., 2004
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001301359 (1)2742 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CR936322 (1)238710 nt
MegaBLAST
PolypeptideUniProtKB:A0A8M1P6F7 (1)739 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanNOP212
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseNop26
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
TSV
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