Gene

wars2

ID

ZDB-GENE-050306-26

Name

tryptophanyl tRNA synthetase 2, mitochondrial

Symbol

wars2 Nomenclature History

Previous Names

zgc:110828 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have tryptophan-tRNA ligase activity. Involved in sprouting angiogenesis. Predicted to localize to cytosol and mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907795 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Wang et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	617710
		Parkinsonism-dystonia 3, childhood-onset	619738

Associated With wars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Family	IPR002305	Aminoacyl-tRNA synthetase, class Ic
Family	IPR002306	Tryptophan-tRNA ligase
Family	IPR024109	Tryptophan-tRNA ligase, bacterial-type
Family	IPR050203	Tryptophan--tRNA ligase
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold