Gene

wars2

ID
ZDB-GENE-050306-26
Name
tryptophanyl tRNA synthetase 2, mitochondrial
Symbol
wars2 Nomenclature History
Previous Names
  • zgc:110828 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have tryptophan-tRNA ligase activity. Involved in sprouting angiogenesis. Predicted to localize to mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Wang et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 617710
Associated With wars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Family IPR002305 Aminoacyl-tRNA synthetase, class Ic
Family IPR002306 Tryptophan-tRNA ligase
Family IPR024109 Tryptophan-tRNA ligase, bacterial-type
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ic Aminoacyl-tRNA synthetase, class I, conserved site Rossmann-like alpha/beta/alpha sandwich fold Tryptophan-tRNA ligase Tryptophan-tRNA ligase, bacterial-type
UniProtKB:B0S5M9 364
UniProtKB:Q5CZN2 364
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-wars2 polyclonal Rabbit
  • WB
Aviva Systems Biology
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations