Gene
gli3
- ID
- ZDB-GENE-041111-162
- Name
- GLI family zinc finger 3
- Symbol
- gli3 Nomenclature History
- Previous Names
-
- fpr (1)
- im:7142603
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in regulation of neurogenesis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Orthologous to human GLI3 (GLI family zinc finger 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142603 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Devine et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Greig cephalopolysyndactyly syndrome | Alliance | Greig cephalopolysyndactyly syndrome | 175700 |
Pallister-Hall syndrome | Alliance | Pallister-Hall syndrome | 146510 |
polydactyly | Alliance | Polydactyly, postaxial, types A1 and B | 174200 |
polydactyly | Alliance | Polydactyly, preaxial, type IV | 174700 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | C2H2-type zinc-finger protein GLI-like | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|
UniProtKB:A0A8M9PLM1
|
728 | |||
UniProtKB:Q6U6Z9
|
1553 | |||
UniProtKB:A0A8M9PFV8
|
876 |
Interactions and Pathways
Plasmids
No data available