Research
General Information
ZIRC
ZFIN: Gene: gli3
ZFIN ID: ZDB-GENE-041111-162

Gene Name:GLI-Kruppel family member GLI3
Gene Symbol: gli3
Previous Names: im:7142603
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 7 figure(s) from 6 publications
Directly submitted expression data: 1 figure(s) (1 images) from Thisse et al., 2004 [IMAGE:7142603]
Wild Type Stages, Structures: Zygote:1-cell (0.00h-0.75h) to Hatching:Pec-fin (60.00h-72.00h)
  diencephalon, forebrain ... (all 17)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   3 genotypes
Allele(s):   hu2162, hu2965, hu2966
Phenotype: (current status)
  Data: 1 figure from Devine et al., 2009
  Observed in: adenohypophysis morphogenesis, spinal cord, spinal cord dorsal/ventral patterning
Knockdown reagents: MO1-gli3 (1) ,   MO2-gli3 (1)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Molecular Function DNA binding (more)
Biological Process generation of neurons (more)
Cellular Component intracellular
All GO Terms (7)

Protein Families, Domains and Sites:
  • InterPro:IPR007087 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR015880 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • Loading Transcript Data...

    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    gli3 Encodes [EST] IMAGE:7142603 (1)    (order this)
    [cDNA] MGC:194808 (1)    (order this)

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205728 (1) 5086 bp
    Polypeptide UniProtKB:Q6U6Z9 (1) 1553 aa
    Sequence Clusters UniGene:99315 (1)
    All Sequence Information (10)

    OTHER  gli3  GENE / MARKER PAGES:

  • Entrez Gene:403042 (1)
  • VEGA:OTTDARG00000018205 (1)
  • Ensembl(Zv8):ENSDARG00000052131 (1)

  • MAPPING INFORMATION:
      LG:  24  Details

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA
    Zebrafish gli3  24
    Human GLI3  7 (p13)
  • OMIM:165240
  • Entrez Gene:2737
  • Mouse Gli3  13 (14.00 cM)
  • MGI:95729
  • Entrez Gene:14634
  • Orthology Details

    CITATIONS   (17)