Gene
hgfa
- ID
- ZDB-GENE-041014-2
- Name
- hepatocyte growth factor a
- Symbol
- hgfa Nomenclature History
- Previous Names
-
- hgf1
- si:dkey-146j3.2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase activity. Involved in cerebellar granule cell differentiation and neuron migration. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and rheumatic disease (multiple). Is expressed in several structures, including DEL; adaxial cell; axis; endodermal cell; and forebrain neural rod. Orthologous to human HGF (hepatocyte growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Isabella et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 39 | Alliance | Deafness, autosomal recessive 39 | 608265 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR003609 | PAN/Apple domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR024174 | Hepatocyte growth factor/Macrophage stimulatory protein |
| Family | IPR027284 | Hepatocyte growth factor |
| Family | IPR050759 | Serine proteases and regulators with kringle domains |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Length | Hepatocyte growth factor | Hepatocyte growth factor/Macrophage stimulatory protein | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | PAN/Apple domain | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases and regulators with kringle domains | Serine proteases, trypsin domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1REK1
|
712 | ||||||||||||
|
UniProtKB:Q5RGG3
|
699 |
Interactions and Pathways
Plasmids
No data available