Gene
tcf12
- ID
- ZDB-GENE-040516-11
- Name
- transcription factor 12
- Symbol
- tcf12 Nomenclature History
- Previous Names
-
- TF12 (1)
- wu:fb74g05
- wu:fc43e06
- zgc:110341
- zgc:85956
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in craniosynostosis. Is expressed in several structures, including central nervous system; cranial vault; mesoderm; neural tube; and presumptive diencephalon. Orthologous to human TCF12 (transcription factor 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110341 (14 images)
- eu268 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
craniosynostosis | Alliance | Craniosynostosis 3 | 615314 |
Hypogonadotropic hypogonadism 26 with or without anosmia | 619718 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neuronal Differentiation E-box Binding Transcription Factors |
---|---|---|---|---|
UniProtKB:A0A0R4IBL7
|
726 | |||
UniProtKB:A0A8M2BDZ2
|
696 | |||
UniProtKB:A0A1L1QZH9
|
713 | |||
UniProtKB:A0A1L1QZA0
|
689 | |||
UniProtKB:A0A1L1QZF4
|
557 | |||
UniProtKB:A0A8M3BB85
|
702 | |||
UniProtKB:A0A8M3B1F3
|
726 | |||
UniProtKB:A0A1L1QZR8
|
551 | |||
UniProtKB:A0A8M3AUH5
|
702 | |||
UniProtKB:A0A9B0A4S3
|
533 | |||
UniProtKB:A0A8M3AUI8
|
720 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
tcf12-201
(1)
|
Havana | 4276 nt | |
mRNA |
tcf12-202
(1)
|
Ensembl | 1817 nt | |
mRNA |
tcf12-203
(1)
|
Havana | 2291 nt | |
mRNA |
tcf12-204
(1)
|
Havana | 513 nt | |
mRNA |
tcf12-205
(1)
|
Havana | 1099 nt | |
mRNA |
tcf12-207
(1)
|
Havana | 4982 nt | |
mRNA |
tcf12-209
(1)
|
Havana | 4875 nt | |
mRNA |
tcf12-210
(1)
|
Havana | 4447 nt | |
mRNA |
tcf12-211
(1)
|
Havana | 4429 nt | |
mRNA |
tcf12-212
(1)
|
Havana | 4431 nt | |
mRNA |
tcf12-213
(1)
|
Havana | 4947 nt | |
mRNA |
tcf12-214
(1)
|
Havana | 749 nt | |
ncRNA |
tcf12-004
(1)
|
Havana | 839 nt | |
ncRNA |
tcf12-009
(1)
|
Havana | 1184 nt |
Interactions and Pathways
No data available
Plasmids
No data available