Gene

tpm1

ID

ZDB-GENE-040426-854

Name

tropomyosin 1 (alpha)

Symbol

tpm1 Nomenclature History

Previous Names

TPM1-1 (1)
zgc:171719
zgc:55951 (1)
zgc:77009

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Is expressed in adaxial cell; heart; and musculature system. Orthologous to human TPM1 (tropomyosin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55951 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpm1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1Y	Alliance	Cardiomyopathy, dilated, 1Y	611878
dilated cardiomyopathy 1Y	Alliance	Left ventricular noncompaction 9	611878
hypertrophic cardiomyopathy 3	Alliance	Cardiomyopathy, hypertrophic, 3	115196

Associated With tpm1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000533	Tropomyosin
Homologous_superfamily	IPR014751	DNA repair protein XRCC4-like, C-terminal

Domain Details Per Protein

Protein	Length	DNA repair protein XRCC4-like, C-terminal	Tropomyosin
UniProtKB:A7E2K1 InterPro	247
UniProtKB:A0A8M9PYA8 InterPro	284
UniProtKB:A0A8M2BLL0 InterPro	284
UniProtKB:A0A8M9P6D8 InterPro	244
UniProtKB:E7FBZ3 InterPro	284
UniProtKB:Q6NYQ0 InterPro	284
UniProtKB:A0A8M9PUV7 InterPro	247
UniProtKB:A0A8M2BLW9 InterPro	244
UniProtKB:A0A2R8RQ88 InterPro	247
UniProtKB:A0A1L6UW63 InterPro	284
UniProtKB:A0A8M3APV7 InterPro	284
UniProtKB:A0A8M2BLM4 InterPro	284
UniProtKB:A0A8M6Z4C1 InterPro	281
UniProtKB:Q7ZVK9 InterPro	284
UniProtKB:A0A8M2BLW8 InterPro	284
UniProtKB:A0A8M3AZU4 InterPro	247

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpm1-201 (1) Ensembl	Ensembl	856 nt	Select Tool ZFIN BLAST
mRNA	tpm1-202 (1) Ensembl	Ensembl	1,742 nt	Select Tool ZFIN BLAST
mRNA	tpm1-203 (1) Ensembl	Ensembl	1,256 nt	Select Tool ZFIN BLAST
mRNA	tpm1-204 (1) Ensembl	Ensembl	1,595 nt	Select Tool ZFIN BLAST
mRNA	tpm1-205 (1) Ensembl	Ensembl	4,826 nt	Select Tool ZFIN BLAST
mRNA	tpm1-206 (1) Ensembl	Ensembl	3,872 nt	Select Tool ZFIN BLAST
mRNA	tpm1-207 (1) Ensembl	Ensembl	4,798 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tpm1	polyclonal	tpm1	IgG	Rabbit	WB	ABclonal	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations