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ZIRC
ZFIN ID: ZDB-GENE-040426-854
Gene Name: tropomyosin 1 (alpha)
Gene Symbol: tpm1    Nomenclature History

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Previous Names: TPM1-1 (1), zgc:171719, zgc:55951 (1), zgc:77009

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to localize to the actin filament. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Is expressed in adaxial cell; heart; and musculature system. Orthologous to human TPM1 (tropomyosin 1).
Genome Resources: Alliance (1),  Gene:393908 (1),  Ensembl(GRCz11):ENSDARG00000087402 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 6 publications
Directly Submitted Expression Data: 7 figures (21 images) from Thisse et al., 2004 [MGC:55951]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023313Tg Transgenic Insertion Unknown Unknown DNA
la028711Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44342 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tpm1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1Y Alliance Cardiomyopathy, dilated, 1Y 611878
    Left ventricular noncompaction 9 611878
    hypertrophic cardiomyopathy 3 Alliance Cardiomyopathy, hypertrophic, 3 115196
    DISEASE ASSOCIATED WITH tpm1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000533 (1)
  • PROSITE:PS00326 (1)
  • Pfam:PF00261 (1)
  • TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tpm1 polyclonal IgG Rabbit WB ABclonal
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpm1 No data available
    MARKER RELATIONSHIPS
    tpm1 Encodes: [cDNA] MGC:55951 (1) (order this), MGC:77009 (1) (order this), MGC:171719 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200934 (1) 1719 bp
    Genomic GenBank:CABZ01046955 (1)
    Polypeptide UniProtKB:A0A1L6UW63 (1) 284 aa
    Sequence Clusters UniGene:103889 (1)
    Sequence Information (all 64)
    ORTHOLOGY for tpm1 ( Chr: 13 )
    CITATIONS (33)