Gene
clic5b
- ID
- ZDB-GENE-040426-2542
- Name
- chloride intracellular channel 5b
- Symbol
- clic5b Nomenclature History
- Previous Names
-
- clic5
- clic5a (1)
- im:6907594
- zgc:77538
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable chloride channel activity and voltage-gated monoatomic ion channel activity. Predicted to act upstream of or within several processes, including chloride transport; glutathione metabolic process; and sensory perception of sound. Predicted to be located in cytoplasm. Predicted to be part of chloride channel complex. Is expressed in digestive system; immature eye; pronephric duct; and sensory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to human CLIC5 (chloride intracellular channel 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907594 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Ott et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 103 | Alliance | ?Deafness, autosomal recessive 103 | 616042 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Domain | IPR042069 | CLIC5, C-terminal GST domain |
| Domain | IPR053823 | CLIC, N-terminal domain |
| Family | IPR002946 | Intracellular chloride channel |
| Family | IPR040079 | Glutathione transferase family |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | CLIC5, C-terminal GST domain | CLIC, N-terminal domain | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione transferase family | Intracellular chloride channel | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A2CEF5
|
243 | |||||||
|
UniProtKB:Q6NXB5
|
408 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
clic5b-201
(1)
|
Ensembl | 2,237 nt | ||
| mRNA |
clic5b-202
(1)
|
Ensembl | 1,003 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-clic5 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available