Gene
igfbp7
- ID
- ZDB-GENE-040426-2423
- Name
- insulin-like growth factor binding protein 7
- Symbol
- igfbp7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within branching involved in blood vessel morphogenesis and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; hypochord; notochord; and pleuroperitoneal region. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85888 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Hooper et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Retinal arterial macroaneurysm with supravalvular pulmonic stenosis | 614224 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR011390 | Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25 |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25 | Kazal domain | Kazal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NW92
|
257 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp7-201
(1)
|
Ensembl | 869 nt | ||
| mRNA |
igfbp7-202
(1)
|
Ensembl | 813 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-igfbp7 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available