ZFIN ID: ZDB-GENE-040426-2423
Gene Name: insulin-like growth factor binding protein 7
Gene Symbol: igfbp7    Nomenclature History

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Previous Names: agm (1), angiomodulin (1), zgc:85888

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits identical protein binding activity. Involved in branching involved in blood vessel morphogenesis and sprouting angiogenesis. Predicted to localize to extracellular region. Is expressed in several structures, including cardiovascular system; central nervous system; hypochord; notochord; and pleuroperitoneal region. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
Genome Resources: Alliance (1),  Gene:405860 (1),  Ensembl(GRCz11):ENSDARG00000104138 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012634Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-igfbp7
    2
    CRISPR2-igfbp7
    2
    MO1-igfbp7 N/A 1
    MO2-igfbp7 N/A 1
    MO3-igfbp7 N/A 1
    DISEASE ASSOCIATED WITH igfbp7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Retinal arterial macroaneurysm with supravalvular pulmonic stenosis 614224
    DISEASE ASSOCIATED WITH igfbp7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process branching involved in blood vessel morphogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA igfbp7-202 (1)    Ensembl 813
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-igfbp7 polyclonal Rabbit IHC Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igfbp7 No data available
    MARKER RELATIONSHIPS
    igfbp7 Contained in: [Fosmid] CH1073-417F17 (1)
    igfbp7 Encodes: [cDNA] cssl:d161 (1), MGC:85888 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212924 (1) 1626 nt
    Genomic GenBank:CU655963 (1) 38845 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IU08 (1) 257 aa
    Sequence Information (all 15)
    ORTHOLOGY for igfbp7 ( Chr: 14 )
    CITATIONS (33)